TARP (gene)

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TCR gamma alternate reading frame protein
Identifiers
Symbol(s) TARP; CD3G; TCRG; TCRGC1; TCRGC2
External IDs OMIM: 609642 HomoloGene: 82822
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 445347 624071
Ensembl ENSG00000211689 n/a
Refseq NM_001003799 (mRNA)
NP_001003799 (protein)		 NM_001081305 (mRNA)
NP_001074774 (protein)
Location Chr 7: 38.27 - 38.27 Mb n/a
Pubmed search [1] [2]

TCR gamma alternate reading frame protein, also known as TARP, is a human gene.[1]

In some non-lymphoid tissues, the unrearranged T cell receptor gamma (TRG@) locus is expressed. The resulting transcript contains a subset of the TRG@ gene segments and is shorter than TRG@ transcripts expressed in lymphoid tissues. This RefSeq record represents the unrearranged TRG@ locus transcript; the complete TRG@ locus is represented by the genomic RefSeq NG_001336. The transcript represented by this RefSeq has two open reading frames (ORFs) that encode different proteins. The downstream ORF is in the same frame as TRG@ and its protein product is similar to TRG@ proteins. The upstream ORF uses a different reading frame and encodes a novel protein.[1]

[edit] References

  1. ^ a b Entrez Gene: TARP TCR gamma alternate reading frame protein.

[edit] Further reading

  • Yoshikai Y, Toyonaga B, Koga Y, et al. (1987). "Repertoire of the human T cell gamma genes: high frequency of nonfunctional transcripts in thymus and mature T cells.". Eur. J. Immunol. 17 (1): 119-26. PMID 2949984. 
  • Krangel MS, Band H, Hata S, et al. (1987). "Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes.". Science 237 (4810): 64-7. PMID 2955517. 
  • Tighe L, Forster A, Clark DM, et al. (1988). "Unusual forms of T cell gamma mRNA in a human T cell leukemia cell line: implications for gamma gene expression.". Eur. J. Immunol. 17 (12): 1729-36. PMID 2961573. 
  • Littman DR, Newton M, Crommie D, et al. (1987). "Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism.". Nature 326 (6108): 85-8. doi:10.1038/326085a0. PMID 3102973. 
  • Pelicci PG, Subar M, Weiss A, et al. (1987). "Molecular diversity of the human T-gamma constant region genes.". Science 237 (4818): 1051-5. PMID 3112943. 
  • Essand M, Vasmatzis G, Brinkmann U, et al. (1999). "High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.". Proc. Natl. Acad. Sci. U.S.A. 96 (16): 9287-92. PMID 10430935. 
  • Wolfgang CD, Essand M, Vincent JJ, et al. (2000). "TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9437-42. doi:10.1073/pnas.160270597. PMID 10931945. 
  • Wolfgang CD, Essand M, Lee B, Pastan I (2001). "T-cell receptor gamma chain alternate reading frame protein (TARP) expression in prostate cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin.". Cancer Res. 61 (22): 8122-6. PMID 11719440. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Cheng WS, Giandomenico V, Pastan I, Essand M (2003). "Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter.". Endocrinology 144 (8): 3433-40. PMID 12865322. 
  • Maeda H, Nagata S, Wolfgang CD, et al. (2004). "The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria.". J. Biol. Chem. 279 (23): 24561-8. doi:10.1074/jbc.M402492200. PMID 15150260. 
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