TARBP1

From Wikipedia, the free encyclopedia

Tar (HIV-1) RNA binding protein 1

PDB rendering based on 2ha8.

Available structures: 2ha8

Identifiers

Symbol(s)

TARBP1; FLJ30482; TRM3; TRP-185; TRP185

External IDs

OMIM: 605052 HomoloGene: 38082

Gene ontology
Molecular Function:	• RNA binding • RNA methyltransferase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • RNA processing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_005646 (mRNA)
NP_005637 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 232.59 - 232.68 Mb

n/a

Pubmed search

[1]

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Tar (HIV-1) RNA binding protein 1, also known as TARBP1, is a human gene.^[1]

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: TARBP1 Tar (HIV-1) RNA binding protein 1.

[edit] Further reading

Sheline CT, Milocco LH, Jones KA (1992). "Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin.". Genes Dev. 5 (12B): 2508-20. PMID 1752441.
Wu F, Garcia J, Sigman D, Gaynor R (1991). "tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.". Genes Dev. 5 (11): 2128-40. PMID 1936997.
Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat.". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153-7. PMID 7638159.
Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.". J. Biol. Chem. 271 (8): 4201-8. PMID 8626763.
Wu-Baer F, Lane WS, Gaynor RB (1996). "The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA.". EMBO J. 14 (23): 5995-6009. PMID 8846792.
Yedavalli VS, Benkirane M, Jeang KT (2003). "Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.". J. Biol. Chem. 278 (8): 6404-10. doi:10.1074/jbc.M209162200. PMID 12458222.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.