TAP2

From Wikipedia, the free encyclopedia

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Identifiers

TAP2; ABC18; ABCB3; APT2; D6S217E; PSF2; RING11

External IDs

OMIM: 170261 MGI: 98484 HomoloGene: 37323

Gene ontology
Molecular Function:	• nucleotide binding • homoaconitate hydratase activity • transporter activity • ATP binding • oligopeptide transporter activity • peptide antigen-transporting ATPase activity • ATPase activity • MHC class I protein binding • phosphate binding • peptide antigen binding • ATPase activity, coupled to transmembrane movement of substances • tapasin binding • protein heterodimerization activity
Cellular Component:	• endoplasmic reticulum • endoplasmic reticulum lumen • cytosol • membrane • integral to membrane • TAP complex
Biological Process:	• protein complex assembly • oligopeptide transport • intracellular protein transport • immune response • peptide transport • antigen processing and presentation of endogenous peptide antigen via MHC class I • cytosol to ER transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000544 (mRNA)
NP_000535 (protein)

NM_011530 (mRNA)
NP_035660 (protein)

Location

Chr 6: 32.9 - 32.91 Mb

Chr 17: 33.81 - 33.83 Mb

Pubmed search

[1]

[2]

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), also known as TAP2, is a human gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.^[1]

1 See also
2 References
3 Further reading
4 External links

[edit] See also

ATP-binding cassette transporter

[edit] References

^ Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP).

[edit] Further reading

Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation.". Semin. Cell Biol. 4 (1): 53-61. PMID 8453065.
Beck S, Kelly A, Radley E, et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.". J. Mol. Biol. 228 (2): 433-41. PMID 1453454.
Bodmer JG, Marsh SG, Albert ED, et al. (1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system.". Tissue Antigens 39 (4): 161-73. PMID 1529427.
Kelly A, Powis SH, Kerr LA, et al. (1992). "Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex.". Nature 355 (6361): 641-4. doi:10.1038/355641a0. PMID 1538751.
Colonna M, Bresnahan M, Bahram S, et al. (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932-6. PMID 1570316.
Powis SH, Mockridge I, Kelly A, et al. (1992). "Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1463-7. PMID 1741401.
Bahram S, Arnold D, Bresnahan M, et al. (1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10094-8. PMID 1946428.
Trowsdale J, Hanson I, Mockridge I, et al. (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.". Nature 348 (6303): 741-4. doi:10.1038/348741a0. PMID 2259383.
de la Salle H, Hanau D, Fricker D, et al. (1994). "Homozygous human TAP peptide transporter mutation in HLA class I deficiency.". Science 265 (5169): 237-41. PMID 7517574.
Cano P, Baxter-Lowe LA (1995). "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain.". Tissue Antigens 45 (2): 139-42. PMID 7792761.
Roby KF, Fei K, Yang Y, Hunt JS (1995). "Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines.". Immunology 83 (3): 444-8. PMID 7835969.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Singal DP, Ye M, Qiu X, D'Souza M (1994). "Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis.". Clin. Exp. Rheumatol. 12 (1): 29-33. PMID 8162639.
Powis SH, Tonks S, Mockridge I, et al. (1993). "Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2.". Immunogenetics 37 (5): 373-80. PMID 8428770.
Glynne R, Kerr LA, Mockridge I, et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing.". Eur. J. Immunol. 23 (4): 860-6. PMID 8458375.
Beck S, Abdulla S, Alderton RP, et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.". J. Mol. Biol. 255 (1): 1-13. doi:10.1006/jmbi.1996.0001. PMID 8568858.
Ahn K, Meyer TH, Uebel S, et al. (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.". EMBO J. 15 (13): 3247-55. PMID 8670825.
Pattanakitsakul S, Takeuchi F, Nabeta H, et al. (1996). "A novel TAP 2 gene RFLP observed in a Japanese.". Tissue Antigens 47 (4): 353-5. PMID 8773329.
Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.". Curr. Biol. 6 (7): 873-83. PMID 8805302.

[edit] External links

MeSH TAP2+protein,+human

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v • d • e Membrane proteins, carrier proteins: membrane transport proteins

ABC-transporter	A1, A2, A3, A4, A7, A8, A12, B1 B2-3, B2, B3, B4, B5, B6, B7, B9, B11 C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11 D1, D2, D3, D4, E1, F1, F2 G1, G2, G4, Sterolin (G5, G8)

Solute carrier	1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1

Monosaccharide	GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9

Other	Amino acid (CD98) - Fatty acid (CD36) - Ion channels - Ion pumps - Mitochondrial membrane transport protein - Neurotransmitter transport proteins - Nuclear (Importin, Karyopherin)