TAP1

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Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
PDB rendering based on 1jj7.
Available structures: 1jj7
Identifiers
Symbol(s) TAP1; APT1; ABC17; ABCB2; D6S114E; FLJ26666; FLJ41500; PSF1; RING4; TAP1*0102N; TAP1N
External IDs OMIM: 170260 MGI: 98483 HomoloGene: 495
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6890 21354
Ensembl ENSG00000168394 ENSMUSG00000037321
Uniprot Q03518 Q3U543
Refseq NM_000593 (mRNA)
NP_000584 (protein)		 NM_013683 (mRNA)
NP_038711 (protein)
Location Chr 6: 32.92 - 32.93 Mb Chr 17: 33.8 - 33.81 Mb
Pubmed search [1] [2]

Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), also known as TAP1, is a human gene.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP).

[edit] Further reading

  • Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation.". Semin. Cell Biol. 4 (1): 53–61. PMID 8453065. 
  • Schölz C, Tampé R (2006). "The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms.". J. Bioenerg. Biomembr. 37 (6): 509–15. doi:10.1007/s10863-005-9500-1. PMID 16691491. 
  • Beck S, Kelly A, Radley E, et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.". J. Mol. Biol. 228 (2): 433–41. PMID 1453454. 
  • Bodmer JG, Marsh SG, Albert ED, et al. (1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system.". Tissue Antigens 39 (4): 161–73. PMID 1529427. 
  • Colonna M, Bresnahan M, Bahram S, et al. (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–6. PMID 1570316. 
  • Bahram S, Arnold D, Bresnahan M, et al. (1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region.". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10094–8. PMID 1946428. 
  • Trowsdale J, Hanson I, Mockridge I, et al. (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters.". Nature 348 (6303): 741–4. doi:10.1038/348741a0. PMID 2259383. 
  • Spies T, Bresnahan M, Bahram S, et al. (1991). "A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway.". Nature 348 (6303): 744–7. doi:10.1038/348744a0. PMID 2259384. 
  • Cerundolo V, Alexander J, Anderson K, et al. (1990). "Presentation of viral antigen controlled by a gene in the major histocompatibility complex.". Nature 345 (6274): 449–52. doi:10.1038/345449a0. PMID 2342577. 
  • Szafer F, Oksenberg JR, Steinman L (1994). "New allelic polymorphisms in TAP genes.". Immunogenetics 39 (5): 374. PMID 8168860. 
  • Jackson DG, Capra JD (1994). "TAP1 alleles in insulin-dependent diabetes mellitus: a newly defined centromeric boundary of disease susceptibility.". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11079–83. PMID 8248212. 
  • Glynne R, Kerr LA, Mockridge I, et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing.". Eur. J. Immunol. 23 (4): 860–6. PMID 8458375. 
  • Beck S, Abdulla S, Alderton RP, et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858. 
  • Chen HL, Gabrilovich D, Tampé R, et al. (1996). "A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer.". Nat. Genet. 13 (2): 210–3. doi:10.1038/ng0696-210. PMID 8640228. 
  • Ahn K, Meyer TH, Uebel S, et al. (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.". EMBO J. 15 (13): 3247–55. PMID 8670825. 
  • Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.". Curr. Biol. 6 (7): 873–83. PMID 8805302. 
  • Nijenhuis M, Hämmerling GJ (1997). "Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.". J. Immunol. 157 (12): 5467–77. PMID 8955196. 
  • Gobin SJ, Wilson L, Keijsers V, Van den Elsen PJ (1997). "Antigen processing and presentation by human trophoblast-derived cell lines.". J. Immunol. 158 (8): 3587–92. PMID 9103419. 
  • Ahn K, Gruhler A, Galocha B, et al. (1997). "The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP.". Immunity 6 (5): 613–21. PMID 9175839. 

[edit] External links

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Membrane proteins, carrier proteins: membrane transport proteins
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B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
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