TAOK2

From Wikipedia, the free encyclopedia

TAO kinase 2

PDB rendering based on 1u5q.

Available structures: 1u5q, 1u5r, 2gcd

Identifiers

Symbol(s)

TAOK2; KIAA0881; MAP3K17; PSK; PSK1; TAO1; TAO2

External IDs

HomoloGene: 74531

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • ATP binding • transferase activity
Cellular Component:	• membrane • integral to membrane • cytoplasmic membrane-bound vesicle
Biological Process:	• activation of MAPKK activity • regulation of cell growth • protein amino acid phosphorylation • protein targeting to membrane • apoptosis • response to stress • regulation of cell shape • cell migration • actin cytoskeleton organization and biogenesis • positive regulation of JNK cascade • focal adhesion formation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_004783 (mRNA)
NP_004774 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 16: 29.89 - 29.91 Mb

n/a

Pubmed search

[1]

n/a

TAO kinase 2, also known as TAOK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TAOK2 TAO kinase 2.

[edit] Further reading

Hutchison M, Berman KS, Cobb MH (1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades.". J. Biol. Chem. 273 (44): 28625–32. PMID 9786855.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Chen Z, Hutchison M, Cobb MH (1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain.". J. Biol. Chem. 274 (40): 28803–7. PMID 10497253.
Moore TM, Garg R, Johnson C, et al. (2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization.". J. Biol. Chem. 275 (6): 4311–22. PMID 10660600.
Chen Z, Cobb MH (2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.". J. Biol. Chem. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mitsopoulos C, Zihni C, Garg R, et al. (2003). "The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.". J. Biol. Chem. 278 (20): 18085–91. doi:10.1074/jbc.M213064200. PMID 12639963.
Chen Z, Raman M, Chen L, et al. (2003). "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.". J. Biol. Chem. 278 (25): 22278–83. doi:10.1074/jbc.M301173200. PMID 12665513.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.". Oncogene 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Huangfu WC, Omori E, Akira S, et al. (2006). "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.". J. Biol. Chem. 281 (39): 28802–10. doi:10.1074/jbc.M603627200. PMID 16893890.
Zihni C, Mitsopoulos C, Tavares IA, et al. (2007). "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.". J. Biol. Chem. 282 (9): 6484–93. doi:10.1074/jbc.M608336200. PMID 17158878.