TANK (gene)

From Wikipedia, the free encyclopedia

TRAF family member-associated NFKB activator

Identifiers

TANK; TRAF2; I-TRAF

External IDs

OMIM: 603893 MGI: 107676 HomoloGene: 3081

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Biological Process:	• signal transduction • I-kappaB kinase/NF-kappaB cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004180 (mRNA)
NP_004171 (protein)

NM_011529 (mRNA)
NP_035659 (protein)

Location

Chr 2: 161.7 - 161.8 Mb

Chr 2: 61.38 - 61.45 Mb

Pubmed search

[1]

[2]

TRAF family member-associated NFKB activator, also known as TANK, is a human gene.^[1]

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TANK TRAF family member-associated NFKB activator.

[edit] Further reading

Rothe M, Xiong J, Shu HB, et al. (1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8241-6. PMID 8710854.
Kaye KM, Devergne O, Harada JN, et al. (1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein.". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 11085-90. PMID 8855313.
Chin AI, Shu J, Shan Shi C, et al. (2000). "TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway.". Mol. Cell. Biol. 19 (10): 6665-72. PMID 10490605.
Pomerantz JL, Baltimore D (2000). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.". EMBO J. 18 (23): 6694-704. doi:10.1093/emboj/18.23.6694. PMID 10581243.
Nomura F, Kawai T, Nakanishi K, Akira S (2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation.". Genes Cells 5 (3): 191-202. PMID 10759890.
Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.". J. Biol. Chem. 276 (26): 24242-52. doi:10.1074/jbc.M100354200. PMID 11279055.
Li C, Ni CZ, Havert ML, et al. (2002). "Downstream regulator TANK binds to the CD40 recognition site on TRAF3.". Structure 10 (3): 403-11. PMID 12005438.
Chariot A, Leonardi A, Muller J, et al. (2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.". J. Biol. Chem. 277 (40): 37029-36. doi:10.1074/jbc.M205069200. PMID 12133833.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ishida R, Ezura Y, Emi M, et al. (2004). "Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women.". Bone 33 (2): 237-41. PMID 14499357.
Li C, Norris PS, Ni CZ, et al. (2004). "Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.". J. Biol. Chem. 278 (50): 50523-9. doi:10.1074/jbc.M309381200. PMID 14517219.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Bonif M, Meuwis MA, Close P, et al. (2006). "TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation.". Biochem. J. 394 (Pt 3): 593-603. doi:10.1042/BJ20051659. PMID 16336209.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Guo B, Cheng G (2007). "Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.". J. Biol. Chem. 282 (16): 11817-26. doi:10.1074/jbc.M700017200. PMID 17327220.
Ryzhakov G, Randow F (2007). "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.". EMBO J. 26 (13): 3180-90. doi:10.1038/sj.emboj.7601743. PMID 17568778.
Gatot JS, Gioia R, Chau TL, et al. (2007). "Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.". J. Biol. Chem. 282 (43): 31131-46. doi:10.1074/jbc.M701690200. PMID 17823124.