TAL2

From Wikipedia, the free encyclopedia

T-cell acute lymphocytic leukemia 2

Identifiers

External IDs

OMIM: 186855 MGI: 99540 HomoloGene: 3954

Gene ontology
Molecular Function:	• DNA binding • protein binding • transcription regulator activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Refseq

NM_005421 (mRNA)
NP_005412 (protein)

NM_009317 (mRNA)
NP_033343 (protein)

Location

Chr 9: 107.46 - 107.47 Mb

Chr 4: 53.8 - 53.81 Mb

Pubmed search

[1]

[2]

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369-74. doi:10.1038/nature02465. PMID 15164053.
Marculescu R, Vanura K, Le T, et al. (2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.". Nat. Genet. 33 (3): 342-4. doi:10.1038/ng1092. PMID 12567187.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Xia Y, Hwang LY, Cobb MH, Baer R (1994). "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.". Oncogene 9 (5): 1437-46. PMID 8152805.
Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831-9. PMID 7957052.
Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416-20. PMID 1763056.
Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood 80 (11): 2858-66. PMID 1450410.