TAL1

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T-cell acute lymphocytic leukemia 1
Identifiers
Symbol(s) TAL1; SCL; TCL5; tal-1
External IDs OMIM: 187040 MGI: 98480 HomoloGene: 2400
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6886 21349
Ensembl ENSG00000162367 ENSMUSG00000028717
Uniprot P17542 Q3TZH7
Refseq NM_003189 (mRNA)
NP_003180 (protein)		 NM_011527 (mRNA)
NP_035657 (protein)
Location Chr 1: 47.45 - 47.47 Mb Chr 4: 114.55 - 114.57 Mb
Pubmed search [1] [2]

T-cell acute lymphocytic leukemia 1, also known as TAL1, is a human gene.[1]

The protein encoded by TAL1 is a basic-helix-loop-helix transcription factor.

[edit] External links

[edit] References

  1. ^ Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1.

[edit] Further reading

  • Green AR, Begley CG (1993). "SCL and related hemopoietic helix-loop-helix transcription factors.". Int. J. Cell Cloning 10 (5): 269–76. PMID 1453013. 
  • Aplan PD, Lombardi DP, Reaman GH, et al. (1992). "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.". Blood 79 (5): 1327–33. PMID 1311214. 
  • Aplan PD, Nakahara K, Orkin SH, Kirsch IR (1992). "The SCL gene product: a positive regulator of erythroid differentiation.". EMBO J. 11 (11): 4073–81. PMID 1396592. 
  • Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood 80 (11): 2858–66. PMID 1450410. 
  • Bernard O, Lecointe N, Jonveaux P, et al. (1991). "Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.". Oncogene 6 (8): 1477–88. PMID 1886719. 
  • Bernard O, Guglielmi P, Jonveaux P, et al. (1991). "Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias.". Genes Chromosomes Cancer 1 (3): 194–208. PMID 1964581. 
  • Chen Q, Yang CY, Tsan JT, et al. (1990). "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.". J. Exp. Med. 172 (5): 1403–8. PMID 2230650. 
  • Aplan PD, Begley CG, Bertness V, et al. (1991). "The SCL gene is formed from a transcriptionally complex locus.". Mol. Cell. Biol. 10 (12): 6426–35. PMID 2247063. 
  • Chen Q, Cheng JT, Tasi LH, et al. (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.". EMBO J. 9 (2): 415–24. PMID 2303035. 
  • Begley CG, Aplan PD, Denning SM, et al. (1990). "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif.". Proc. Natl. Acad. Sci. U.S.A. 86 (24): 10128–32. PMID 2602361. 
  • Finger LR, Kagan J, Christopher G, et al. (1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5039–43. PMID 2740341. 
  • Osada H, Grutz G, Axelson H, et al. (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. PMID 7568177. 
  • Pulford K, Lecointe N, Leroy-Viard K, et al. (1995). "Expression of TAL-1 proteins in human tissues.". Blood 85 (3): 675–84. PMID 7833471. 
  • Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. PMID 7957052. 
  • Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. PMID 8078932. 
  • Cross MA, Heyworth CM, Murrell AM, et al. (1994). "Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line.". Oncogene 9 (10): 3013–6. PMID 8084606. 
  • Hsu HL, Wadman I, Baer R (1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. PMID 8159721. 
  • Hwang LY, Siegelman M, Davis L, et al. (1993). "Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen.". Oncogene 8 (11): 3043–6. PMID 8414504. 
  • Cheng JT, Cobb MH, Baer R (1993). "Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1.". Mol. Cell. Biol. 13 (2): 801–8. PMID 8423803. 
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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD