TAGLN

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Transgelin
PDB rendering based on 1ujo.
Available structures: 1ujo
Identifiers
Symbol(s) TAGLN; SMCC; DKFZp686P11128; SM22; TAGLN1; WS3-10
External IDs OMIM: 600818 MGI: 106012 HomoloGene: 2398
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6876 21345
Ensembl ENSG00000149591 ENSMUSG00000032085
Uniprot Q01995 P37804
Refseq NM_001001522 (mRNA)
NP_001001522 (protein)		 NM_011526 (mRNA)
NP_035656 (protein)
Location Chr 11: 116.58 - 116.58 Mb Chr 9: 45.68 - 45.69 Mb
Pubmed search [1] [2]

Transgelin, also known as TAGLN, is a human gene.[1]

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: TAGLN transgelin.

[edit] Further reading

  • Thweatt R, Lumpkin CK, Goldstein S (1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts.". Biochem. Biophys. Res. Commun. 187 (1): 1–7. PMID 1520290. 
  • Nishida W, Kitami Y, Abe M, Hiwada K (1991). "Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle.". Biochem. Int. 23 (4): 663–8. PMID 1872880. 
  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527. 
  • Kobayashi R, Kubota T, Hidaka H (1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog.". Biochem. Biophys. Res. Commun. 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Li L, Liu Z, Mercer B, et al. (1997). "Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells.". Dev. Biol. 187 (2): 311–21. PMID 9242426. 
  • Yamamura H, Masuda H, Ikeda W, et al. (1997). "Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation.". J. Biochem. 122 (1): 157–67. PMID 9276683. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Lawson D, Harrison M, Shapland C (1998). "Fibroblast transgelin and smooth muscle SM22alpha are the same protein, the expression of which is down-regulated in many cell lines.". Cell Motil. Cytoskeleton 38 (3): 250–7. doi:10.1002/(SICI)1097-0169(1997)38:3<250::AID-CM3>3.0.CO;2-9. PMID 9384215. 
  • Camoretti-Mercado B, Forsythe SM, LeBeau MM, et al. (1998). "Expression and cytogenetic localization of the human SM22 gene (TAGLN).". Genomics 49 (3): 452–7. doi:10.1006/geno.1998.5267. PMID 9615232. 
  • Fu Y, Liu HW, Forsythe SM, et al. (2001). "Mutagenesis analysis of human SM22: characterization of actin binding.". J. Appl. Physiol. 89 (5): 1985–90. PMID 11053353. 
  • Shields JM, Rogers-Graham K, Der CJ (2002). "Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.". J. Biol. Chem. 277 (12): 9790–9. doi:10.1074/jbc.M110086200. PMID 11773051. 
  • Chainiaux F, Magalhaes JP, Eliaers F, et al. (2002). "UVB-induced premature senescence of human diploid skin fibroblasts.". Int. J. Biochem. Cell Biol. 34 (11): 1331–9. PMID 12200029. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Xu R, Ho YS, Ritchie RP, Li L (2003). "Human SM22 alpha BAC encompasses regulatory sequences for expression in vascular and visceral smooth muscles at fetal and adult stages.". Am. J. Physiol. Heart Circ. Physiol. 284 (4): H1398–407. doi:10.1152/ajpheart.00737.2002. PMID 12521938. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Yang Z, Chang YJ, Miyamoto H, et al. (2007). "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth.". Mol. Endocrinol. 21 (2): 343–58. doi:10.1210/me.2006-0104. PMID 17082327. 
  • Liao X, Li S, Lou Z, et al. (2007). "Crystallization and preliminary crystallographic analysis of transgelin.". Protein Pept. Lett. 14 (2): 209–11. PMID 17305610. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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