TAF6

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TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
Identifiers
Symbol(s) TAF6; DKFZp781E21155; MGC:8964; TAF2E; TAFII70; TAFII80; TAFII85
External IDs OMIM: 602955 MGI: 109129 HomoloGene: 7561
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6878 21343
Ensembl ENSG00000106290 ENSMUSG00000036980
Uniprot P49848 Q62311
Refseq NM_005641 (mRNA)
NP_005632 (protein)		 NM_009315 (mRNA)
NP_033341 (protein)
Location Chr 7: 99.54 - 99.55 Mb Chr 5: 138.41 - 138.42 Mb
Pubmed search [1] [2]

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa, also known as TAF6, is a human gene.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Four isoforms have been identified but complete transcripts have been determined for only three isoforms. One of the isoforms has been shown to preclude binding of one of the other TFIID subunits, thereby reducing transcription and initiating signals that trigger apoptosis.[1]

[edit] References

  1. ^ Entrez Gene: TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa.

[edit] Further reading

  • Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. PMID 7597030. 
  • Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. PMID 7644498. 
  • Hisatake K, Ohta T, Takada R, et al. (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195–9. PMID 7667268. 
  • Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat.". EMBO J. 14 (2): 321–8. PMID 7835343. 
  • Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.". J. Biol. Chem. 270 (5): 2274–83. PMID 7836461. 
  • Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.". J. Virol. 68 (11): 7188–99. PMID 7933101. 
  • Kashanchi F, Piras G, Radonovich MF, et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat.". Nature 367 (6460): 295–9. doi:10.1038/367295a0. PMID 8121496. 
  • Weinzierl RO, Ruppert S, Dynlacht BD, et al. (1994). "Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID.". EMBO J. 12 (13): 5303–9. PMID 8262073. 
  • Wang Z, Morris GF, Rice AP, et al. (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro.". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. PMID 8680883. 
  • Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly.". J. Virol. 70 (8): 5025–34. PMID 8764009. 
  • Kashanchi F, Khleif SN, Duvall JF, et al. (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex.". J. Virol. 70 (8): 5503–10. PMID 8764062. 
  • Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.". Science 274 (5287): 605–10. PMID 8849451. 
  • Tao Y, Guermah M, Martinez E, et al. (1997). "Specific interactions and potential functions of human TAFII100.". J. Biol. Chem. 272 (10): 6714–21. PMID 9045704. 
  • García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.". J. Biol. Chem. 272 (11): 6951–8. PMID 9054383. 
  • Mahanta SK, Scholl T, Yang FC, Strominger JL (1997). "Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein.". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6324–9. PMID 9177216. 
  • Guermah M, Malik S, Roeder RG (1998). "Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1.". Mol. Cell. Biol. 18 (6): 3234–44. PMID 9584164. 
  • Brand M, Moggs JG, Oulad-Abdelghani M, et al. (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation.". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMID 11406595. 
  • Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMID 11564863. 
  • Bell B, Scheer E, Tora L (2001). "Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function.". Mol. Cell 8 (3): 591–600. PMID 11583621. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
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