TAF4B

From Wikipedia, the free encyclopedia

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa

Identifiers

TAF4B; TAF2C2; TAFII105

External IDs

OMIM: 601689 MGI: 2152345 HomoloGene: 28266

Gene ontology
Molecular Function:	• transcription factor activity • transcription initiation factor activity • NF-kappaB binding
Cellular Component:	• nucleus • transcription factor TFIID complex
Biological Process:	• transcription • transcription initiation • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

XM_290809 (mRNA)
XP_290809 (protein)

XM_128905 (mRNA)
XP_128905 (protein)

Location

Chr 18: 22.06 - 22.22 Mb

Chr 18: 14.98 - 15.04 Mb

Pubmed search

[1]

[2]

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa, also known as TAF4B, is a human gene.^[1]

TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa.

[edit] Further reading

Liu WL, Coleman RA, Grob P, et al. (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity.". Mol. Cell 29 (1): 81-91. doi:10.1016/j.molcel.2007.11.003. PMID 18206971.
Wu Y, Lu Y, Hu Y, Li R (2006). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line.". J. Cell. Biochem. 96 (4): 751-9. doi:10.1002/jcb.20577. PMID 16088961.
Shao H, Revach M, Moshonov S, et al. (2005). "Core promoter binding by histone-like TAF complexes.". Mol. Cell. Biol. 25 (1): 206-19. doi:10.1128/MCB.25.1.206-219.2005. PMID 15601843.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Rashevsky-Finkel A, Silkov A, Dikstein R (2002). "A composite nuclear export signal in the TBP-associated factor TAFII105.". J. Biol. Chem. 276 (48): 44963-9. doi:10.1074/jbc.M106112200. PMID 11567023.
Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes.". J. Biol. Chem. 275 (24): 18180-7. PMID 10849440.
Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription.". J. Biol. Chem. 275 (22): 16459-65. PMID 10828057.
Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB.". EMBO J. 17 (17): 5161-9. doi:10.1093/emboj/17.17.5161. PMID 9724652.
Dikstein R, Zhou S, Tjian R (1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.". Cell 87 (1): 137-46. PMID 8858156.