TAF1

From Wikipedia, the free encyclopedia

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

PDB rendering based on 1eqf.

Available structures: 1eqf

Identifiers

Symbol(s)

TAF1; NSCL2; OF; BA2R; CCG1; CCGS; P250; TAF2A; TAFII250

External IDs

OMIM: 313650 MGI: 1336878 HomoloGene: 37942

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • histone acetyltransferase activity • protein serine/threonine kinase activity • protein binding • ATP binding • kinase activity • transferase activity
Cellular Component:	• nucleus • transcription factor TFIID complex
Biological Process:	• G1 phase of mitotic cell cycle • transcription • transcription initiation • regulation of transcription, DNA-dependent • cell cycle • protein amino acid autophosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004606 (mRNA)
NP_004597 (protein)

XM_001000569 (mRNA)
XP_001000569 (protein)

Location

Chr X: 70.5 - 70.67 Mb

Chr X: 97.74 - 97.8 Mb

Pubmed search

[1]

[2]

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa, also known as TAF1, is a human gene.

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two transcripts encoding different isoforms have been identified for this gene.^[1]

[edit] See also

Transcription Factor II D

[edit] References

^ Entrez Gene: TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa.

[edit] Further reading

Wassarman DA, Sauer F (2002). "TAF(II)250: a transcription toolbox.". J. Cell. Sci. 114 (Pt 16): 2895-902. PMID 11686293.
Ha I, Lane WS, Reinberg D (1991). "Cloning of a human gene encoding the general transcription initiation factor IIB.". Nature 352 (6337): 689-95. doi:10.1038/352689a0. PMID 1876184.
Sekiguchi T, Nohiro Y, Nakamura Y, et al. (1991). "The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein.". Mol. Cell. Biol. 11 (6): 3317-25. PMID 2038334.
Sekiguchi T, Miyata T, Nishimoto T (1988). "Molecular cloning of the cDNA of human X chromosomal gene (CCG1) which complements the temperature-sensitive G1 mutants, tsBN462 and ts13, of the BHK cell line.". EMBO J. 7 (6): 1683-7. PMID 3169001.
Sekiguchi T, Yoshida MC, Sekiguchi M, Nishimoto T (1987). "Isolation of a human X chromosome-linked gene essential for progression from G1 to S phase of the cell cycle.". Exp. Cell Res. 169 (2): 395-407. PMID 3556424.
Ruppert S, Tjian R (1995). "Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation.". Genes Dev. 9 (22): 2747-55. PMID 7590250.
Hisatake K, Ohta T, Takada R, et al. (1995). "Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 92 (18): 8195-9. PMID 7667268.
Ruppert S, Wang EH, Tjian R (1993). "Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation.". Nature 362 (6416): 175-9. doi:10.1038/362175a0. PMID 7680771.
Shao Z, Ruppert S, Robbins PD (1995). "The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3115-9. PMID 7724524.
DeJong J, Bernstein R, Roeder RG (1995). "Human general transcription factor TFIIA: characterization of a cDNA encoding the small subunit and requirement for basal and activated transcription.". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3313-7. PMID 7724559.
Thut CJ, Chen JL, Klemm R, Tjian R (1995). "p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60.". Science 267 (5194): 100-4. PMID 7809597.
Zhou Q, Sharp PA (1995). "Novel mechanism and factor for regulation by HIV-1 Tat.". EMBO J. 14 (2): 321-8. PMID 7835343.
Parada CA, Yoon JB, Roeder RG (1995). "A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.". J. Biol. Chem. 270 (5): 2274-83. PMID 7836461.
Jacq X, Brou C, Lutz Y, et al. (1994). "Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor.". Cell 79 (1): 107-17. PMID 7923369.
Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.". J. Virol. 68 (11): 7188-99. PMID 7933101.
Sun X, Ma D, Sheldon M, et al. (1994). "Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription.". Genes Dev. 8 (19): 2336-48. PMID 7958900.
Metz R, Bannister AJ, Sutherland JA, et al. (1994). "c-Fos-induced activation of a TATA-box-containing promoter involves direct contact with TATA-box-binding protein.". Mol. Cell. Biol. 14 (9): 6021-9. PMID 8065335.
Kashanchi F, Piras G, Radonovich MF, et al. (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat.". Nature 367 (6460): 295-9. doi:10.1038/367295a0. PMID 8121496.
Nakashima T, Sekiguchi T, Sunamoto H, et al. (1994). "Structure of the human CCG1 gene: relationship between the exons/introns and functional domain/modules of the protein.". Gene 141 (2): 193-200. PMID 8163188.
Ma D, Watanabe H, Mermelstein F, et al. (1993). "Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription.". Genes Dev. 7 (11): 2246-57. PMID 8224850.