TAF1B

From Wikipedia, the free encyclopedia

TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa

Identifiers

TAF1B; SL1; MGC:9349; RAF1B; RAFI63; TAFI63

External IDs

OMIM: 604904 MGI: 109577 HomoloGene: 31331

Gene ontology
Molecular Function:	• transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005680 (mRNA)
NP_005671 (protein)

XM_973112 (mRNA)
XP_978206 (protein)

Location

Chr 2: 9.9 - 9.99 Mb

Chr 12: 25.09 - 25.15 Mb

Pubmed search

[1]

[2]

TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa, also known as TAF1B, is a human gene.^[1]

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.^[1]

[edit] References

^ ^a ^b Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa.

[edit] Further reading

Comai L, Zomerdijk JC, Beckmann H, et al. (1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.". Science 266 (5193): 1966-72. PMID 7801123.
Di Pietro C, Rapisarda A, Amico V, et al. (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1.". Cytogenet. Cell Genet. 89 (1-2): 133-6. PMID 10894955.
Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53.". Mol. Cell. Biol. 20 (16): 5930-8. PMID 10913176.
Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.". EMBO J. 20 (6): 1373-82. doi:10.1093/emboj/20.6.1373. PMID 11250903.
Kim NG, Rhee H, Li LS, et al. (2002). "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability.". Oncogene 21 (33): 5081-7. doi:10.1038/sj.onc.1205703. PMID 12140758.
Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.". EMBO Rep. 3 (11): 1082-7. doi:10.1093/embo-reports/kvf212. PMID 12393749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Grandori C, Gomez-Roman N, Felton-Edkins ZA, et al. (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.". Nat. Cell Biol. 7 (3): 311-8. doi:10.1038/ncb1224. PMID 15723054.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724-31. doi:10.1038/nature03466. PMID 15815621.
You KT, Li LS, Kim NG, et al. (2007). "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.". PLoS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMID 17456004.