TAF1A

From Wikipedia, the free encyclopedia

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

Identifiers

TAF1A; SL1; MGC:17061; RAFI48; TAFI48

External IDs

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase I transcription factor activity • protein binding • general RNA polymerase II transcription factor activity
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase I promoter • transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_005681 (mRNA)
NP_005672 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 1: 220.8 - 220.83 Mb

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Pubmed search

[1]

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TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa, also known as TAF1A, is a human gene.^[1]

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa.

[edit] Further reading

Comai L, Zomerdijk JC, Beckmann H, et al. (1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits.". Science 266 (5193): 1966–72. PMID 7801123.
Rudloff U, Eberhard D, Tora L, et al. (1994). "TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription.". EMBO J. 13 (11): 2611–6. PMID 8013460.
Di Pietro C, Rapisarda A, Amico V, et al. (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1.". Cytogenet. Cell Genet. 89 (1-2): 133–6. PMID 10894955.
Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53.". Mol. Cell. Biol. 20 (16): 5930–8. PMID 10913176.
Seo SB, McNamara P, Heo S, et al. (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein.". Cell 104 (1): 119–30. PMID 11163245.
Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters.". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMID 11250903.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dynes JL, Xu S, Bothner S, et al. (2005). "The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors.". J. Biochem. 135 (3): 429–38. PMID 15113842.
Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMID 15226435.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Grandori C, Gomez-Roman N, Felton-Edkins ZA, et al. (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I.". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.