Talk:Tadalafil

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This article states that Lilly bought Icos in 2006. That is incorrect. Icos still has not been purchased and maybe never will.----

Eli Lilly purchased ICOS Corporation for $2.3 billion dollars in 2007.71.113.78.21 (talk) 12:59, 10 February 2008 (UTC)

As with Levitra, I just had to put that bit in about what to do if a certain body part remains hard for more than four hours.

JesseG 00:31, 16 Jun 2004 (UTC)

Contents

[edit] Levitra and cialis difference

Levitra and cialis both are PDE5 inhibitors and in which way do they differ in performance, price, customer satisfaction, Any clarifications please?

Levitra is not used much, so studies comparing "customer satisfaction" have been done between the more widely used Cialis and Viagra, and have not shown much difference. The main difference between the 3 drugs (Levitra, Viagra, and Cialis) is the duration of action/pharmacologic half-life of Cialis, which is mentioned in the article. Levitra and Cialis have similar pharmacologic properties (half-life, duration of action, time of onset) and efficacy, with Cialis being more widely used due to "first to market" and familiar branding71.113.78.21 (talk) 13:02, 10 February 2008 (UTC)

[edit] Comparison with other drugs

I've made a request for more information about how this drug compares to similar ones. I think other people would like to know more about this too. Thanks to anyone who can help. Eje211 16:57, 9 May 2006 (UTC)

A great in-depth article can be found here, in which the three drugs are compared. Tadalafil has a different binding-mode than Sildenafil or Vardenafil, which are structurally very similar.

[edit] Cialis Drug History cleanup

The section is confusing; it talks about Pfizer as if it were a drug, whereas Pfizer is the company that owns Viagra. The statement that Cialis works for up to 36 hours occurs twice in the last two sentences. And the whole thing needs to sourced. -- Donald Albury 10:17, 28 October 2006 (UTC)

[edit] cleaning...

Corrected the confusion between company (Pfizer) and drug (Viagra). The statement about the effect duration depends on the half-life of the substance. Both the mesured halfe-life and the advertised effect duration can be found in any drug data base. The problem is : most drug database are restricted to physician. The few public I know are in french. I don't know which source to mention here. Help ! DrYak 13:36, 24 November 2006 (UTC)

If you don't know of any publicly accessible source in English, cite a French one. If someone finds a source in English, it can always be added then. .-- Donald Albury 16:48, 24 November 2006 (UTC)

[edit] Niagara means 'waterfall' in latin??

According to this article the word "Niagara" means 'waterfall' in latin. But according to the Niagara Falls article, "The name "Niagara" is said to originate from an Iroquois word "Onguiaahra" meaning "The Strait." " SO WHATS THE DEAL???

Another reading of that sentence is that the name Viagra is derived from the Latin vita and from the name of the waterfall, which does not imply that 'Niagara' is from Latin. However, the whole thing is unsourced. -- Donald Albury 11:05, 26 November 2006 (UTC)

[edit] Spam

How about a section that says something like "Cialis has a bad reputation for being offered through spam"? --71.125.20.130 21:39, 15 December 2006 (UTC)

As opposed to all the other drugs that are not offered through e-mail spam? -- Donald Albury 02:20, 17 December 2006 (UTC)
Mostly this and Viagra are in spam, I would say it's significant and notable 84.9.98.2 08:53, 2 May 2007 (UTC)

[edit] Causes erections?

"...caused the heart patients that were participating in a clinical study of a heart medicine to have erections..."

Surely this is wrong or incorrectly phrased?

The FDA-approved package insert[1] for Cialis says "Some form of sexual stimulation is needed for an erection to happen with CIALIS." Dpbsmith (talk) 13:10, 30 December 2006 (UTC)

Slightly incorrectly phrased. As part of the clinical development procedure, all drugs go through a First in Man clinical trial. As it's the first time the drug has been tested in humans, all partipants are healthy young males.
As any young male can testify, you don't really need much stimulation to obtain an erection, let alone with chemical assistance. If you're still skeptical, bear in mind that FIM trials are usually closely monitored by medical staff, which include nurses. :) Oni no Akuma 07:11, 12 September 2007 (UTC)
Ooops, forgot to mention, this was how sildenafil was discovered. The line you've highlighted is discussing the history of viagra and how that drug has affected the development of cialis. Oni no Akuma 11:11, 13 September 2007 (UTC)

The aforementionned statement "Some form of sexual stimulation is needed for an erection to happen with CIALIS" is correct. The pivotal clinical trials conducted with Cialis were in men with erectile dysfunction, and "spontaneous erections" were rare (as indicated in the label). After Cialis use, sexual stimulation is required to initiate an erection. 71.113.78.21 (talk) 13:11, 10 February 2008 (UTC)

[edit] Unique SMILES formula

Should anyone want to add it to the infobox (with | smiles=<formula>), the Unique SMILES formula is

CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c5ccc6OCOc6c5)C1=O

71.41.210.146 05:12, 29 April 2007 (UTC)

[edit] encouraging competition

The article, presumably sponsored by Eli Lilly omits to mention that other brands of Tadalafil are available e.g. Forzest from Ranbaxy Pharmaceuticals.

Tadalafil is still under patent by Eli Lilly and a generic version is not available by Ranbaxy Pharmaceuticals. Similarly, Forzest is one of many "online" pharmacies located outside of the US that advertises "generic tadalafil".71.113.78.21 (talk) 13:11, 10 February 2008 (UTC)

Also confirmed that "Some form of sexual stimulation is needed for an erection to happen with Tadalafil"

[edit] Mechanisms of action

the part at the end where it says that:

"Right heart failure and pulmonary oedema are the main consequences of pulmonary arterial hypertension"

is incorrect. Right heart failure causes edema of the extremities, not the lungs, —Preceding unsigned comment added by User38934 (talk • contribs) 01:14, 10 May 2008 (UTC)