TADA2L

From Wikipedia, the free encyclopedia

Transcriptional adaptor 2 (ADA2 homolog, yeast)-like

PDB rendering based on 1x41.

Available structures: 1x41, 2aqe, 2aqf, 2cuj

Identifiers

Symbol(s)

TADA2L; ADA2; FLJ12705; KL04P; hADA2

External IDs

OMIM: 602276 MGI: 2144471 HomoloGene: 38834

Gene ontology
Molecular Function:	• DNA binding • transcription factor activity • transcription cofactor activity • zinc ion binding
Cellular Component:	• nucleus • spliceosome • chromosome
Biological Process:	• regulation of progression through cell cycle • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • mRNA processing • cell cycle • RNA splicing • regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001488 (mRNA)
NP_001479 (protein)

NM_172562 (mRNA)
NP_766150 (protein)

Location

Chr 17: 32.84 - 32.91 Mb

Chr 11: 83.9 - 83.94 Mb

Pubmed search

[1]

[2]

Transcriptional adaptor 2 (ADA2 homolog, yeast)-like, also known as TADA2L, is a human gene.^[1]

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Candau R, Moore PA, Wang L, et al. (1996). "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5.". Mol. Cell. Biol. 16 (2): 593–602. PMID 8552087.
Wang L, Mizzen C, Ying C, et al. (1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation.". Mol. Cell. Biol. 17 (1): 519–27. PMID 8972232.
Carter KC, Wang L, Shell BK, et al. (1997). "The human transcriptional adaptor genes TADA2L and GCN5L2 colocalize to chromosome 17q12-q21 and display a similar tissue expression pattern.". Genomics 40 (3): 497–500. doi:10.1006/geno.1996.4605. PMID 9073520.
Henriksson A, Almlöf T, Ford J, et al. (1997). "Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor.". Mol. Cell. Biol. 17 (6): 3065–73. PMID 9154805.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ogryzko VV, Kotani T, Zhang X, et al. (1998). "Histone-like TAFs within the PCAF histone acetylase complex.". Cell 94 (1): 35–44. PMID 9674425.
Vassilev A, Yamauchi J, Kotani T, et al. (1999). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily.". Mol. Cell 2 (6): 869–75. PMID 9885574.
Wang T, Kobayashi T, Takimoto R, et al. (2002). "hADA3 is required for p53 activity.". EMBO J. 20 (22): 6404–13. doi:10.1093/emboj/20.22.6404. PMID 11707411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Barlev NA, Emelyanov AV, Castagnino P, et al. (2003). "A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription.". Mol. Cell. Biol. 23 (19): 6944–57. PMID 12972612.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Qian C, Zhang Q, Li S, et al. (2006). "Structure and chromosomal DNA binding of the SWIRM domain.". Nat. Struct. Mol. Biol. 12 (12): 1078–85. doi:10.1038/nsmb1022. PMID 16299514.