TAC3

From Wikipedia, the free encyclopedia

Tachykinin 3 (neuromedin K, neurokinin beta)

Identifiers

TAC3; NKB; NKNB; PRO1155; ZNEUROK1

External IDs

OMIM: 162330 MGI: 98476 HomoloGene: 7560

Gene ontology
Molecular Function:	• receptor binding
Cellular Component:	• extracellular space • soluble fraction
Biological Process:	• tachykinin signaling pathway • neuropeptide signaling pathway • female pregnancy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001006667 (mRNA)
NP_001006668 (protein)

NM_009312 (mRNA)
NP_033338 (protein)

Location

Chr 12: 55.69 - 55.7 Mb

Chr 10: 127.13 - 127.13 Mb

Pubmed search

[1]

[2]

Tachykinin 3 (neuromedin K, neurokinin beta), also known as TAC3, is a human gene.^[1]

[edit] References

^ Entrez Gene: TAC3 tachykinin 3 (neuromedin K, neurokinin beta).

[edit] Further reading

Page NM, Woods RJ, Lowry PJ (2001). "A regulatory role for neurokinin B in placental physiology and pre-eclampsia.". Regul. Pept. 98 (3): 97-104. PMID 11231038.
Rance NE, Young WS (1991). "Hypertrophy and increased gene expression of neurons containing neurokinin-B and substance-P messenger ribonucleic acids in the hypothalami of postmenopausal women.". Endocrinology 128 (5): 2239-47. PMID 1708331.
Bonner TI, Affolter HU, Young AC, Young WS (1988). "A cDNA encoding the precursor of the rat neuropeptide, neurokinin B.". Brain Res. 388 (3): 243-9. PMID 3479225.
Bhogal N, Donnelly D, Findlay JB (1994). "The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor.". J. Biol. Chem. 269 (44): 27269-74. PMID 7961636.
Tian Y, Wu LH, Oxender DL, Chung FZ (1996). "The unpredicted high affinities of a large number of naturally occurring tachykinins for chimeric NK1/NK3 receptors suggest a role for an inhibitory domain in determining receptor specificity.". J. Biol. Chem. 271 (34): 20250-7. PMID 8702757.
Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310-5. PMID 8990205.
Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.". Neuropeptides 32 (3): 215-23. PMID 10189055.
Page NM, Woods RJ, Gardiner SM, et al. (2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.". Nature 405 (6788): 797-800. doi:10.1038/35015579. PMID 10866201.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Brownbill P, Bell NJ, Woods RJ, et al. (2003). "Neurokinin B is a paracrine vasodilator in the human fetal placental circulation.". J. Clin. Endocrinol. Metab. 88 (5): 2164-70. PMID 12727971.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Schlembach D, Scalera F, Fischer T, et al. (2003). "Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women.". Am. J. Obstet. Gynecol. 189 (5): 1418-22. PMID 14634580.
Laliberte C, DiMarzo L, Morrish DW, Kaufman S (2004). "Neurokinin B causes concentration-dependent relaxation of isolated human placental resistance vessels.". Regul. Pept. 117 (2): 123-6. PMID 14700748.
Pal S, Nemeth MJ, Bodine D, et al. (2004). "Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1.". J. Biol. Chem. 279 (30): 31348-56. doi:10.1074/jbc.M403475200. PMID 15123623.
Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM (2005). "Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles.". J. Biomol. Struct. Dyn. 22 (2): 137-48. PMID 15317475.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia.". Mol. Hum. Reprod. 12 (7): 427-33. doi:10.1093/molehr/gal025. PMID 16709596.