Tabersonine 16-hydroxylase

From Wikipedia, the free encyclopedia

In enzymology, a tabersonine 16-hydroxylase (EC 1.14.13.73) is an enzyme that catalyzes the chemical reaction

tabersonine + NADPH + H⁺ + O₂ 16-hydroxytabersonine + NADP⁺ + H₂O

The 4 substrates of this enzyme are tabersonine, NADPH, H⁺, and O₂, whereas its 3 products are 16-hydroxytabersonine, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating). Other names in common use include tabersonine-11-hydroxylase, and T11H. This enzyme participates in indole and ipecac alkaloid biosynthesis.

[edit] References

• IUBMB entry for 1.14.13.73
• BRENDA references for 1.14.13.73 (Recommended.)
• PubMed references for 1.14.13.73
• PubMed Central references for 1.14.13.73
• Google Scholar references for 1.14.13.73
• St-Pierre B, De Luca V (1995). "A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus". Plant. Physiol. 109: 131–139. PMID 12228585. 

[edit] External links

The CAS registry number for this enzyme class is 250378-34-8.

• IUBMB entry for 1.14.13.73

• KEGG entry for 1.14.13.73

• BRENDA entry for 1.14.13.73

• NiceZyme view of 1.14.13.73

• EC2PDB: PDB structures for 1.14.13.73

• PRIAM entry for 1.14.13.73

• PUMA2 entry for 1.14.13.73

• IntEnz: Integrated Enzyme entry for 1.14.13.73

• MetaCyc entry for 1.14.13.73

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050594: tabersonine 16-hydroxylase

• AMIGO entry for GO code 0050594: tabersonine 16-hydroxylase