T cell vaccination
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T cell vaccination is immunization with inactivated autoreactive T cells. The concept of T cell vaccination is, at least partially, analogous to classical vaccination against infectious disease. However, the agents to be eliminated or neutralized are not foreign microbial agents but a pathogenic autoreactive T cell population. Research on T cell vaccination so far has focussed mostly on multiple sclerosis and to a lesser extent on rheumatoid arthritis, Crohn's disease and AIDS.
[edit] References
- Zhang J (2002). "T-cell vaccination for autoimmune diseases: immunologic lessons and clinical experience in multiple sclerosis". Expert Rev Vaccines 1 (3): 285–92. doi:. PMID 12901569.
- McMichael A, Mwau M, Hanke T (2002). "HIV T cell vaccines, the importance of clades". Vaccine 20 (15): 1918–21. doi:. PMID 11983245.
- Hellings N, Raus J, Stinissen P (2004). "T-cell vaccination in multiple sclerosis: update on clinical application and mode of action". Autoimmun Rev 3 (4): 267–75. doi:. PMID 15246022.
- Cohen IR (2001). "T-cell vaccination for autoimmune disease: a panorama". Vaccine 20 (5-6): 706–10. doi:. PMID 11738733.
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