T-cell lymphoma invasion and metastasis-inducing protein 1

From Wikipedia, the free encyclopedia

T-cell lymphoma invasion and metastasis 1

PDB rendering based on 1foe.

Available structures: 1foe, 2d8i

Identifiers

Symbol(s)

TIAM1; FLJ36302

External IDs

OMIM: 600687 MGI: 103306 HomoloGene: 2443

Gene ontology
Molecular Function:	• receptor signaling protein activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • protein binding • phospholipid binding • ephrin receptor binding
Cellular Component:	• intracellular • plasma membrane
Biological Process:	• signal transduction • small GTPase mediated signal transduction • regulation of Rho protein signal transduction • ephrin receptor signaling pathway • positive regulation of axonogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003253 (mRNA)
NP_003244 (protein)

NM_009384 (mRNA)
NP_033410 (protein)

Location

Chr 21: 31.41 - 31.85 Mb

Chr 16: 89.68 - 90.03 Mb

Pubmed search

[1]

[2]

T-cell lymphoma invasion and metastasis-inducing protein 1, also known as TIAM1, is a human protein gene.^[1]

It modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of Rho-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. It is tightly associate with BAIAP2 as a subunit.

It was found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain.

[edit] References

^ Entrez Gene: TIAM1 T-cell lymphoma invasion and metastasis 1.

[edit] Further reading

Habets GG, van der Kammen RA, Stam JC, et al. (1995). "Sequence of the human invasion-inducing TIAM1 gene, its conservation in evolution and its expression in tumor cell lines of different tissue origin.". Oncogene 10 (7): 1371–6. PMID 7731688.
Habets GG, van der Kammen RA, Jenkins NA, et al. (1995). "The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.". Cytogenet. Cell Genet. 70 (1-2): 48–51. PMID 7736788.
Michiels F, Habets GG, Stam JC, et al. (1995). "A role for Rac in Tiam1-induced membrane ruffling and invasion.". Nature 375 (6529): 338–40. doi:10.1038/375338a0. PMID 7753201.
Chen H, Antonarakis SE (1996). "Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1.". Genomics 30 (1): 123–7. doi:10.1006/geno.1995.0025. PMID 8595894.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Michiels F, Stam JC, Hordijk PL, et al. (1997). "Regulated membrane localization of Tiam1, mediated by the NH2-terminal pleckstrin homology domain, is required for Rac-dependent membrane ruffling and C-Jun NH2-terminal kinase activation.". J. Cell Biol. 137 (2): 387–98. PMID 9128250.
Fleming IN, Elliott CM, Buchanan FG, et al. (1999). "Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation.". J. Biol. Chem. 274 (18): 12753–8. PMID 10212259.
Bourguignon LY, Zhu H, Shao L, Chen YW (2000). "CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration.". J. Biol. Chem. 275 (3): 1829–38. PMID 10636882.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Crompton AM, Foley LH, Wood A, et al. (2000). "Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands.". J. Biol. Chem. 275 (33): 25751–9. doi:10.1074/jbc.M002050200. PMID 10835422.
Bourguignon LY, Zhu H, Shao L, Chen YW (2000). "Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration.". J. Cell Biol. 150 (1): 177–91. PMID 10893266.
Worthylake DK, Rossman KL, Sondek J (2001). "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.". Nature 408 (6813): 682–8. doi:10.1038/35047014. PMID 11130063.
Otsuki Y, Tanaka M, Yoshii S, et al. (2001). "Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4385–90. doi:10.1073/pnas.071411598. PMID 11274357.
Gao Y, Xing J, Streuli M, et al. (2002). "Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors.". J. Biol. Chem. 276 (50): 47530–41. doi:10.1074/jbc.M108865200. PMID 11595749.
Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade.". Mol. Cell. Biol. 22 (12): 4073–85. PMID 12024021.
Lambert JM, Lambert QT, Reuther GW, et al. (2002). "Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.". Nat. Cell Biol. 4 (8): 621–5. doi:10.1038/ncb833. PMID 12134164.
Wennerberg K, Ellerbroek SM, Liu RY, et al. (2003). "RhoG signals in parallel with Rac1 and Cdc42.". J. Biol. Chem. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
Otsuki Y, Tanaka M, Kamo T, et al. (2003). "Guanine nucleotide exchange factor, Tiam1, directly binds to c-Myc and interferes with c-Myc-mediated apoptosis in rat-1 fibroblasts.". J. Biol. Chem. 278 (7): 5132–40. doi:10.1074/jbc.M206733200. PMID 12446731.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Buchsbaum RJ, Connolly BA, Feig LA (2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin.". J. Biol. Chem. 278 (21): 18833–41. doi:10.1074/jbc.M207876200. PMID 12531897.