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| T-box leader |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
Barrick JE, predicted; Vitreschak A, PubMed |
| Avg length: |
226.8 nucleotides |
| Avg identity: |
46% |
|
The T-box leader element is involved in the regulation of translation associated genes, usually in gram-positive bacteria. Typically T-box leaders are found upstream of aminoacyl-tRNA synthetase genes and some amino acid biosynthetic genes. Uncharged tRNA acts as the effector for transcription antitermination of genes in the T-box leader family [1][2][3]. The anticodon of a specific tRNA base pairs to a specifier sequence within the T-box motif, and the NCCA acceptor tail of the tRNA base pairs to a conserved bulge in the T-box antiterminator hairpin [4].
[edit] References
- ^ Grundy, FJ; Rollins SM, Henkin TM (1994). "Interaction between the acceptor end of tRNA and the T box stimulates antitermination in the Bacillus subtilis tyrS gene: a new role for the discriminator base". J Bacteriol 176: 4518–4526. PMID 8045882.
- ^ Grundy, FJ; Collins JA, Rollins SM, Henkin TM (2000). "tRNA determinants for transcription antitermination of the Bacillus subtilis tyrS gene". RNA 6: 1131–1141. doi:10.1017/S1355838200992100. PMID 10943892.
- ^ Winkler, WC; Grundy FJ, Murphy BA, Henkin TM (2001). "The GA motif: an RNA element common to bacterial antitermination systems, rRNA, and eukaryotic RNAs". RNA 7: 1165–1172. doi:10.1017/S1355838201002370. PMID 11497434.
- ^ Gerdeman, MS; Henkin TM, Hines JV (2003). "Solution structure of the Bacillus subtilis T-box antiterminator RNA: seven nucleotide bulge characterized by stacking and flexibility". J Mol Biol 326: 189–201. doi:10.1016/S0022-2836(02)01339-6. PMID 12547201.
[edit] External links
