SYTL2

From Wikipedia, the free encyclopedia

Synaptotagmin-like 2

Identifiers

SYTL2; CHR11SYT; KIAA1597; MGC102768; SGA72M; SLP2

External IDs

MGI: 1933366 HomoloGene: 12854

Gene ontology
Molecular Function:	• transporter activity • Rab GTPase binding • phosphopantetheine binding • neurexin binding
Cellular Component:	• membrane fraction • synaptic vesicle • membrane • extrinsic to plasma membrane • melanosome
Biological Process:	• transport • intracellular protein transport • vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_032379 (mRNA)
NP_115755 (protein)

XM_984573 (mRNA)
XP_989667 (protein)

Location

Chr 11: 85.08 - 85.15 Mb

Chr 7: 90.22 - 90.29 Mb

Pubmed search

[1]

[2]

Synaptotagmin-like 2, also known as SYTL2, is a human gene.^[1]

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.^[1]

[edit] References

^ ^a ^b Entrez Gene: SYTL2 synaptotagmin-like 2.

[edit] Further reading

Nalefski EA, Falke JJ (1997). "The C2 domain calcium-binding motif: structural and functional diversity.". Protein Sci. 5 (12): 2375-90. PMID 8976547.
Duncan RR, Shipston MJ, Chow RH (2000). "Double C2 protein. A review.". Biochimie 82 (5): 421-6. PMID 10865129.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491-6. PMID 10737800.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273-81. PMID 10997877.
Fukuda M, Mikoshiba K (2001). "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins.". Biochem. Biophys. Res. Commun. 281 (5): 1226-33. doi:10.1006/bbrc.2001.4512. PMID 11243866.
Fukuda M, Saegusa C, Mikoshiba K (2001). "Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain.". Biochem. Biophys. Res. Commun. 283 (2): 513-9. doi:10.1006/bbrc.2001.4803. PMID 11327731.
Craxton M (2001). "Genomic analysis of synaptotagmin genes.". Genomics 77 (1-2): 43-9. doi:10.1006/geno.2001.6619. PMID 11543631.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.". J. Biol. Chem. 277 (11): 9212-8. doi:10.1074/jbc.M112414200. PMID 11773082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.". J. Biol. Chem. 278 (17): 15390-6. doi:10.1074/jbc.M213090200. PMID 12590134.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Yu M, Kasai K, Nagashima K, et al. (2007). "Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain.". Mol. Biol. Cell 18 (2): 688-96. doi:10.1091/mbc.E06-10-0914. PMID 17182843.