SYTL1

From Wikipedia, the free encyclopedia

Synaptotagmin-like 1

Identifiers

SYTL1; FLJ14996; JFC1; SLP1

External IDs

OMIM: 608042 MGI: 1933365 HomoloGene: 12853

Gene ontology
Molecular Function:	• transporter activity • protein binding • ATP binding • zinc ion binding • Rab GTPase binding • neurexin binding • hydrogen ion transporting ATP synthase activity, rotational mechanism • hydrogen ion transporting ATPase activity, rotational mechanism
Cellular Component:	• membrane fraction • soluble fraction • synaptic vesicle • membrane • proton-transporting two-sector ATPase complex • extrinsic to plasma membrane • melanosome
Biological Process:	• intracellular protein transport • ATP synthesis coupled proton transport • vesicle-mediated transport

Orthologs

Human

Mouse

Refseq

NM_032872 (mRNA)
NP_116261 (protein)

NM_031393 (mRNA)
NP_113570 (protein)

Location

Chr 1: 27.54 - 27.55 Mb

Chr 4: 132.53 - 132.54 Mb

Pubmed search

[1]

[2]

Synaptotagmin-like 1, also known as SYTL1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SYTL1 synaptotagmin-like 1.

[edit] Further reading

Fukuda M, Mikoshiba K (2001). "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins.". Biochem. Biophys. Res. Commun. 281 (5): 1226–33. doi:10.1006/bbrc.2001.4512. PMID 11243866.
McAdara Berkowitz JK, Catz SD, Johnson JL, et al. (2001). "JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase.". J. Biol. Chem. 276 (22): 18855–62. doi:10.1074/jbc.M011167200. PMID 11278853.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.". J. Biol. Chem. 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082.
Strom M, Hume AN, Tarafder AK, et al. (2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.". J. Biol. Chem. 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908.
Catz SD, Babior BM, Johnson JL (2002). "JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells.". Biochem. J. 367 (Pt 3): 791–9. doi:10.1042/BJ20020345. PMID 12137562.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Johnson JL, Ellis BA, Noack D, et al. (2006). "The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase.". Biochem. J. 391 (Pt 3): 699–710. doi:10.1042/BJ20050380. PMID 16004602.
Schmid M, Fellermann K, Fritz P, et al. (2007). "Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease.". J. Leukoc. Biol. 81 (4): 907–15. doi:10.1189/jlb.0906581. PMID 17200145.