SYT4

From Wikipedia, the free encyclopedia

Synaptotagmin IV

PDB rendering based on 1ugk.

Available structures: 1ugk, 1w15, 1w16

Identifiers

Symbol(s)

SYT4; HsT1192; KIAA1342

External IDs

OMIM: 600103 MGI: 101759 HomoloGene: 7559

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding
Cellular Component:	• synaptic vesicle • membrane • integral to membrane • neuron projection • synapse • perinuclear region of cytoplasm
Biological Process:	• transport • neurotransmitter secretion • regulation of calcium ion-dependent exocytosis • synaptic vesicle transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020783 (mRNA)
NP_065834 (protein)

NM_009308 (mRNA)
NP_033334 (protein)

Location

Chr 18: 39.1 - 39.11 Mb

Chr 18: 31.58 - 31.59 Mb

Pubmed search

[1]

[2]

Synaptotagmin IV, also known as SYT4, is a human gene.^[1]

[edit] References

^ Entrez Gene: SYT4 synaptotagmin IV.

[edit] Further reading

Ullrich B, Li C, Zhang JZ, et al. (1995). "Functional properties of multiple synaptotagmins in brain.". Neuron 13 (6): 1281-91. PMID 7993622.
Hilbush BS, Morgan JI (1994). "A third synaptotagmin gene, Syt3, in the mouse.". Proc. Natl. Acad. Sci. U.S.A. 91 (17): 8195-9. PMID 8058779.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry 35 (43): 13808-16. doi:10.1021/bi960853x. PMID 8901523.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV.". Mol. Biol. Cell 10 (7): 2285-95. PMID 10397765.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823-31. PMID 10734137.
Ferguson GD, Chen XN, Korenberg JR, Herschman HR (2001). "The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.". J. Biol. Chem. 275 (47): 36920-6. doi:10.1074/jbc.M005801200. PMID 10938284.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.