SYT2

From Wikipedia, the free encyclopedia

Synaptotagmin II

Identifiers

SYT2; SytII

External IDs

OMIM: 600104 MGI: 99666 HomoloGene: 22516

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding • protein binding • calcium-dependent phospholipid binding
Cellular Component:	• plasma membrane • synaptic vesicle • integral to membrane • vesicular fraction • synapse
Biological Process:	• transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_177402 (mRNA)
NP_796376 (protein)

NM_009307 (mRNA)
NP_033333 (protein)

Location

Chr 1: 200.83 - 200.95 Mb

Chr 1: 136.53 - 136.57 Mb

Pubmed search

[1]

[2]

Synaptotagmin II, also known as SYT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SYT2 synaptotagmin II.

[edit] Further reading

Jones JM, Popma SJ, Mizuta M, et al. (1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19.". Mamm. Genome 6 (3): 212–3. PMID 7749232.
Fukuda M, Aruga J, Niinobe M, et al. (1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.". J. Biol. Chem. 269 (46): 29206–11. PMID 7961887.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Baram D, Adachi R, Medalia O, et al. (1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells.". J. Exp. Med. 189 (10): 1649–58. PMID 10330444.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823–31. PMID 10734137.
Kida Y, Sakaguchi M, Fukuda M, et al. (2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum.". J. Cell Biol. 150 (4): 719–30. PMID 10952998.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.". J. Cell Biol. 153 (5): 1111–20. PMID 11381094.
Kida Y, Sakaguchi M, Fukuda M, et al. (2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II.". FEBS Lett. 507 (3): 341–5. PMID 11696368.
Lindmark IM, Karlsson A, Serrander L, et al. (2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils.". Biochim. Biophys. Acta 1590 (1-3): 159–66. PMID 12063179.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rickman C, Archer DA, Meunier FA, et al. (2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate.". J. Biol. Chem. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
Lee BH, Min X, Heise CJ, et al. (2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.". Mol. Cell 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.