SYT1

From Wikipedia, the free encyclopedia

Synaptotagmin I

PDB rendering based on 1byn.

Available structures: 1byn, 1k5w, 1rsy, 1tjm, 1tjx, 1uov, 1uow

Identifiers

Symbol(s)

SYT1; SYT; DKFZp781D2042; P65; SVP65

External IDs

OMIM: 185605 MGI: 99667 HomoloGene: 4122

Gene ontology
Molecular Function:	• transporter activity • calcium ion binding • protein binding • phospholipid binding • phosphatidylinositol binding • syntaxin-1 binding • low-density lipoprotein receptor binding
Cellular Component:	• integral to membrane • secretory granule • synaptic vesicle membrane • presynaptic membrane • neuron projection • synapse
Biological Process:	• detection of calcium ion • transport • synaptic transmission • neurotransmitter secretion • regulation of exocytosis • protein homooligomerization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005639 (mRNA)
NP_005630 (protein)

NM_009306 (mRNA)
NP_033332 (protein)

Location

Chr 12: 77.78 - 78.37 Mb

Chr 10: 107.9 - 108.42 Mb

Pubmed search

[1]

[2]

Synaptotagmin I, also known as SYT1, is a human gene.

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: SYT1 synaptotagmin I.

[edit] Further reading

Mochly-Rosen D, Miller KG, Scheller RH, et al. (1992). "p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.". Biochemistry 31 (35): 8120-4. PMID 1326322.
Perin MS, Johnston PA, Ozcelik T, et al. (1991). "Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.". J. Biol. Chem. 266 (1): 615-22. PMID 1840599.
McMahon HT, Missler M, Li C, Südhof TC (1995). "Complexins: cytosolic proteins that regulate SNAP receptor function.". Cell 83 (1): 111-9. PMID 7553862.
O'Regan S, Diebler MF, Meunier FM, Vyas S (1995). "A Ewing's sarcoma cell line showing some, but not all, of the traits of a cholinergic neuron.". J. Neurochem. 64 (1): 69-76. PMID 7798952.
Zhang JZ, Davletov BA, Südhof TC, Anderson RG (1994). "Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling.". Cell 78 (5): 751-60. PMID 8087843.
Chapman ER, Blasi J, An S, et al. (1996). "Fatty acylation of synaptotagmin in PC12 cells and synaptosomes.". Biochem. Biophys. Res. Commun. 225 (1): 326-32. doi:10.1006/bbrc.1996.1174. PMID 8769138.
Perin MS (1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin.". Biochemistry 35 (43): 13808-16. doi:10.1021/bi960853x. PMID 8901523.
Betz A, Okamoto M, Benseler F, Brose N (1997). "Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.". J. Biol. Chem. 272 (4): 2520-6. PMID 8999968.
Shao X, Li C, Fernandez I, et al. (1997). "Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch.". Neuron 18 (1): 133-42. PMID 9010211.
Charvin N, L'evêque C, Walker D, et al. (1997). "Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel.". EMBO J. 16 (15): 4591-6. doi:10.1093/emboj/16.15.4591. PMID 9303303.
Mouta Carreira C, LaVallee TM, Tarantini F, et al. (1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro.". J. Biol. Chem. 273 (35): 22224-31. PMID 9712836.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV.". Mol. Biol. Cell 10 (7): 2285-95. PMID 10397765.
Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes.". J. Biol. Chem. 275 (9): 6328-36. PMID 10692432.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823-31. PMID 10734137.
Kimura N, Shiraishi S, Mizunashi K, et al. (2001). "Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line.". J. Histochem. Cytochem. 49 (3): 341-6. PMID 11181737.
Fernández-Chacón R, Königstorfer A, Gerber SH, et al. (2001). "Synaptotagmin I functions as a calcium regulator of release probability.". Nature 410 (6824): 41-9. doi:10.1038/35065004. PMID 11242035.
Fukuda M, Mikoshiba K (2001). "Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins.". Biochem. Biophys. Res. Commun. 281 (5): 1226-33. doi:10.1006/bbrc.2001.4512. PMID 11243866.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.". J. Cell Biol. 153 (5): 1111-20. PMID 11381094.
Landriscina M, Bagalá C, Mandinova A, et al. (2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.". J. Biol. Chem. 276 (27): 25549-57. doi:10.1074/jbc.M102925200. PMID 11432880.
Coppola T, Magnin-Luthi S, Perret-Menoud V, et al. (2001). "Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin.". J. Biol. Chem. 276 (35): 32756-62. doi:10.1074/jbc.M100929200. PMID 11438518.