SYNPO

From Wikipedia, the free encyclopedia

Synaptopodin

Identifiers

SYNPO; KIAA1029

External IDs

OMIM: 608155 MGI: 1099446 HomoloGene: 5274

Gene ontology
Molecular Function:	• actin binding
Cellular Component:	• actin cytoskeleton • dendritic spine
Biological Process:	• cortical cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007286 (mRNA)
NP_009217 (protein)

XM_894564 (mRNA)
XP_899657 (protein)

Location

Chr 5: 149.96 - 150.02 Mb

Chr 18: 60.72 - 60.76 Mb

Pubmed search

[1]

[2]

Synaptopodin, also known as SYNPO, is a human gene.^[1]

Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SYNPO synaptopodin.

[edit] Further reading

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3–174. PMID 7566098.
Mundel P, Heid HW, Mundel TM, et al. (1998). "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes.". J. Cell Biol. 139 (1): 193–204. PMID 9314539.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Patrie KM, Drescher AJ, Welihinda A, et al. (2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.". J. Biol. Chem. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. PMID 12042308.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
He JC, Husain M, Sunamoto M, et al. (2004). "Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways.". J. Clin. Invest. 114 (5): 643–51. doi:10.1172/JCI200421004. PMID 15343382.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Kremerskothen J, Plaas C, Kindler S, et al. (2005). "Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein.". J. Neurochem. 92 (3): 597–606. doi:10.1111/j.1471-4159.2004.02888.x. PMID 15659229.
Asanuma K, Kim K, Oh J, et al. (2005). "Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.". J. Clin. Invest. 115 (5): 1188–98. doi:10.1172/JCI200523371. PMID 15841212.
Husain M, D'Agati VD, He JC, et al. (2006). "HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN.". AIDS 19 (17): 1975–80. PMID 16260903.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Hirakawa M, Tsuruya K, Yotsueda H, et al. (2006). "Expression of synaptopodin and GLEPP1 as markers of steroid responsiveness in primary focal segmental glomerulosclerosis.". Life Sci. 79 (8): 757–63. doi:10.1016/j.lfs.2006.02.031. PMID 16564554.
Asanuma K, Yanagida-Asanuma E, Faul C, et al. (2006). "Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling.". Nat. Cell Biol. 8 (5): 485–91. doi:10.1038/ncb1400. PMID 16622418.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Garovic VD, Wagner SJ, Petrovic LM, et al. (2007). "Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia.". Nephrol. Dial. Transplant. 22 (4): 1136–43. doi:10.1093/ndt/gfl711. PMID 17255128.