SYNGAP1

From Wikipedia, the free encyclopedia

Synaptic Ras GTPase activating protein 1 homolog (rat)

Identifiers

SYNGAP1; RASA1; DKFZp761G1421; KIAA1938; RASA5; SYNGAP

External IDs

OMIM: 603384 MGI: 3039785 HomoloGene: 84739

Gene ontology
Molecular Function:	• GTPase activator activity
Cellular Component:	• intracellular
Biological Process:	• regulation of small GTPase mediated signal transduction

Orthologs

Human

Mouse

Entrez

8831

240057

Refseq

NM_006772 (mRNA)
NP_006763 (protein)

XM_915205 (mRNA)
XP_920298 (protein)

Pubmed search

[1]

[2]

Synaptic Ras GTPase activating protein 1 homolog (rat), also known as SYNGAP1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SYNGAP1 synaptic Ras GTPase activating protein 1 homolog (rat).

[edit] Further reading

Fantl WJ, Escobedo JA, Martin GA, et al. (1992). "Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways.". Cell 69 (3): 413-23. PMID 1374684.
Kroll J, Waltenberger J (1998). "The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells.". J. Biol. Chem. 272 (51): 32521-7. PMID 9405464.
Kim JH, Liao D, Lau LF, Huganir RL (1998). "SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.". Neuron 20 (4): 683-91. PMID 9581761.
Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.". Neuron 20 (5): 895-904. PMID 9620694.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661-9. doi:10.1038/76615. PMID 10862698.
Li W, Okano A, Tian QB, et al. (2001). "Characterization of a novel synGAP isoform, synGAP-beta.". J. Biol. Chem. 276 (24): 21417-24. doi:10.1074/jbc.M010744200. PMID 11278737.
Pei L, Teves RL, Wallace MC, Gurd JW (2001). "Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP.". J. Cereb. Blood Flow Metab. 21 (8): 955-63. doi:10.1097/00004647-200108000-00008. PMID 11487731.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins.". DNA Res. 8 (4): 179-87. PMID 11572484.
Yi J, Kloeker S, Jensen CC, et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers.". J. Biol. Chem. 277 (11): 9580-9. doi:10.1074/jbc.M106922200. PMID 11782456.
Kim JH, Lee HK, Takamiya K, Huganir RL (2003). "The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity.". J. Neurosci. 23 (4): 1119-24. PMID 12598599.
Song B, Meng F, Yan X, et al. (2003). "Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.". Neurosci. Lett. 349 (3): 183-6. PMID 12951199.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Oh JS, Manzerra P, Kennedy MB (2004). "Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II.". J. Biol. Chem. 279 (17): 17980-8. doi:10.1074/jbc.M314109200. PMID 14970204.
Tomoda T, Kim JH, Zhan C, Hatten ME (2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth.". Genes Dev. 18 (5): 541-58. doi:10.1101/gad.1151204. PMID 15014045.
Song B, Yan XB, Zhang GY (2004). "PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus.". Brain Res. 1005 (1-2): 44-50. doi:10.1016/j.brainres.2004.01.032. PMID 15044063.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Krapivinsky G, Medina I, Krapivinsky L, et al. (2004). "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.". Neuron 43 (4): 563-74. doi:10.1016/j.neuron.2004.08.003. PMID 15312654.
Jaffe H, Vinade L, Dosemeci A (2004). "Identification of novel phosphorylation sites on postsynaptic density proteins.". Biochem. Biophys. Res. Commun. 321 (1): 210-8. doi:10.1016/j.bbrc.2004.06.122. PMID 15358237.