SYNE2

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Spectrin repeat containing, nuclear envelope 2
Identifiers
Symbol(s) SYNE2; DKFZP434H2235; DKFZp686E01115; DKFZp686H1931; FLJ11014; FLJ43727; FLJ45710; FLJ46790; KIAA1011; NUA; NUANCE; Nesprin-2; SYNE-2
External IDs OMIM: 608442 MGI: 2449316 HomoloGene: 56700
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23224 319565
Ensembl ENSG00000054654 ENSMUSG00000063450
Uniprot Q8WXH0 n/a
Refseq NM_182912 (mRNA)
NP_878916 (protein)		 XM_001001846 (mRNA)
XP_001001846 (protein)
Location Chr 14: 63.39 - 63.76 Mb Chr 12: 76.83 - 77.03 Mb
Pubmed search [1] [2]

Spectrin repeat containing, nuclear envelope 2, also known as SYNE2, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: SYNE2 spectrin repeat containing, nuclear envelope 2.

[edit] Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032. 
  • Apel ED, Lewis RM, Grady RM, Sanes JR (2000). "Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.". J. Biol. Chem. 275 (41): 31986–95. doi:10.1074/jbc.M004775200. PMID 10878022. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Zhang Q, Skepper JN, Yang F, et al. (2002). "Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.". J. Cell. Sci. 114 (Pt 24): 4485–98. PMID 11792814. 
  • Zhen YY, Libotte T, Munck M, et al. (2003). "NUANCE, a giant protein connecting the nucleus and actin cytoskeleton.". J. Cell. Sci. 115 (Pt 15): 3207–22. PMID 12118075. 
  • Zhang Q, Ragnauth C, Greener MJ, et al. (2003). "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.". Genomics 80 (5): 473–81. PMID 12408964. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
  • Schirmer EC, Florens L, Guan T, et al. (2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics.". Science 301 (5638): 1380–2. doi:10.1126/science.1088176. PMID 12958361. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Zhang Q, Ragnauth CD, Skepper JN, et al. (2005). "Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle.". J. Cell. Sci. 118 (Pt 4): 673–87. doi:10.1242/jcs.01642. PMID 15671068. 
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807. 
  • Libotte T, Zaim H, Abraham S, et al. (2005). "Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.". Mol. Biol. Cell 16 (7): 3411–24. doi:10.1091/mbc.E04-11-1009. PMID 15843432. 
  • Padmakumar VC, Libotte T, Lu W, et al. (2005). "The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.". J. Cell. Sci. 118 (Pt 15): 3419–30. doi:10.1242/jcs.02471. PMID 16079285. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Wheeler MA, Davies JD, Zhang Q, et al. (2007). "Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.". Exp. Cell Res. 313 (13): 2845–57. doi:10.1016/j.yexcr.2007.03.025. PMID 17462627. 
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