SYNCRIP

From Wikipedia, the free encyclopedia

Synaptotagmin binding, cytoplasmic RNA interacting protein

PDB rendering based on 2dgu.

Available structures: 2dgu

Identifiers

Symbol(s)

SYNCRIP; GRY-RBP; HNRPQ1; NSAP1; RP1-3J17.2; dJ3J17.2; pp68

External IDs

MGI: 1891690 HomoloGene: 4648

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • RNA binding • protein binding • poly(A) binding
Cellular Component:	• nucleus • spliceosome • cytoplasm • endoplasmic reticulum
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006372 (mRNA)
NP_006363 (protein)

NM_019666 (mRNA)
NP_062640 (protein)

Location

Chr 6: 86.37 - 86.41 Mb

Chr 9: 88.25 - 88.28 Mb

Pubmed search

[1]

[2]

Synaptotagmin binding, cytoplasmic RNA interacting protein, also known as SYNCRIP, is a human gene.^[1]

[edit] References

^ Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Fu C, Chan AC (1997). "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.". J. Biol. Chem. 272 (43): 27362–8. PMID 9341187.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Harris CE, Boden RA, Astell CR (1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice.". J. Virol. 73 (1): 72–80. PMID 9847309.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms.". J. Biol. Chem. 275 (13): 9823–31. PMID 10734137.
Grosset C, Chen CY, Xu N, et al. (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.". Cell 103 (1): 29–40. PMID 11051545.
Blanc V, Navaratnam N, Henderson JO, et al. (2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing.". J. Biol. Chem. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.
Lau PP, Chang BH, Chan L (2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome.". Biochem. Biophys. Res. Commun. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
Mourelatos Z, Abel L, Yong J, et al. (2001). "SMN interacts with a novel family of hnRNP and spliceosomal proteins.". EMBO J. 20 (19): 5443–52. doi:10.1093/emboj/20.19.5443. PMID 11574476.
Rossoll W, Kröning AK, Ohndorf UM, et al. (2002). "Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?". Hum. Mol. Genet. 11 (1): 93–105. PMID 11773003.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. PMID 11991638.
Hresko RC, Mueckler M (2002). "Identification of pp68 as the Tyrosine-phosphorylated Form of SYNCRIP/NSAP1. A cytoplasmic RNA-binding protein.". J. Biol. Chem. 277 (28): 25233–8. doi:10.1074/jbc.M202556200. PMID 11994298.
Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing.". Mol. Cell Proteomics 1 (8): 598–610. PMID 12376575.
Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons.". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hinsby AM, Olsen JV, Bennett KL, Mann M (2003). "Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry.". Mol. Cell Proteomics 2 (1): 29–36. PMID 12601080.
Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D).". Biol. Chem. 384 (1): 25–37. PMID 12674497.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Kim JH, Paek KY, Ha SH, et al. (2004). "A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon.". Mol. Cell. Biol. 24 (18): 7878–90. doi:10.1128/MCB.24.18.7878-7890.2004. PMID 15340051.