SYN3

From Wikipedia, the free encyclopedia

Synapsin III

PDB rendering based on 2p0a.

Available structures: 2p0a

Identifiers

Symbol(s)

SYN3;

External IDs

OMIM: 602705 MGI: 1351334 HomoloGene: 68320

Gene ontology
Molecular Function:	• nucleotide binding • catalytic activity • calcium ion binding • ATP binding
Cellular Component:	• synaptic vesicle • synaptic vesicle membrane • synapse
Biological Process:	• neurotransmitter secretion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003490 (mRNA)
NP_003481 (protein)

NM_013722 (mRNA)
NP_038750 (protein)

Location

Chr 22: 31.24 - 31.73 Mb

Chr 10: 85.49 - 85.9 Mb

Pubmed search

[1]

[2]

Synapsin III, also known as SYN3, is a human gene.^[1]

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in six transcript variants; however, only two variants have been fully described.^[1]

[edit] References

^ ^a ^b Entrez Gene: SYN3 synapsin III.

[edit] Further reading

Kao HT, Porton B, Czernik AJ, et al. (1998). "A third member of the synapsin gene family.". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4667–72. PMID 9539796.
Hosaka M, Südhof TC (1999). "Homo- and heterodimerization of synapsins.". J. Biol. Chem. 274 (24): 16747–53. PMID 10358015.
Kao HT, Porton B, Hilfiker S, et al. (2000). "Molecular evolution of the synapsin gene family.". J. Exp. Zool. 285 (4): 360–77. PMID 10578110.
Porton B, Kao HT, Greengard P (1999). "Characterization of transcripts from the synapsin III gene locus.". J. Neurochem. 73 (6): 2266–71. PMID 10582583.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Tsai MT, Hung CC, Tsai CY, et al. (2002). "Mutation analysis of synapsin III gene in schizophrenia.". Am. J. Med. Genet. 114 (1): 79–83. PMID 11840510.
Jaffrey SR, Benfenati F, Snowman AM, et al. (2002). "Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 3199–204. doi:10.1073/pnas.261705799. PMID 11867766.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Porton B, Ferreira A, DeLisi LE, Kao HT (2004). "A rare polymorphism affects a mitogen-activated protein kinase site in synapsin III: possible relationship to schizophrenia.". Biol. Psychiatry 55 (2): 118–25. PMID 14732590.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lachman HM, Stopkova P, Rafael MA, Saito T (2005). "Association of schizophrenia in African Americans to polymorphism in synapsin III gene.". Psychiatr. Genet. 15 (2): 127–32. PMID 15900227.
Lachman HM, Stopkova P, Papolos DF, et al. (2006). "Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder.". Neuropsychobiology 53 (2): 57–62. doi:10.1159/000091720. PMID 16511335.
Makkar R, Gomez L, Wigg KG, et al. (2007). "The gene for synapsin III and attention-deficit hyperactivity disorder.". Psychiatr. Genet. 17 (2): 109–12. doi:10.1097/YPG.0b013e328012a0c6. PMID 17413450.