SYCP3

From Wikipedia, the free encyclopedia

Synaptonemal complex protein 3

Identifiers

SYCP3; SCP3; COR1; MGC71888

External IDs

OMIM: 604759 MGI: 109542 HomoloGene: 7964

Gene ontology
Molecular Function:	• DNA binding • protein binding
Cellular Component:	• condensed chromosome • lateral element • transverse filament • nucleus
Biological Process:	• achiasmate meiosis I • cell cycle • female meiosis sister chromatid cohesion • mitosis • meiosis • synaptonemal complex assembly • male meiosis I • spermatogenesis • spermatogenesis, exchange of chromosomal proteins • negative regulation of apoptosis • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_153694 (mRNA)
NP_710161 (protein)

NM_011517 (mRNA)
NP_035647 (protein)

Location

Chr 12: 100.65 - 100.66 Mb

Chr 10: 87.89 - 87.9 Mb

Pubmed search

[1]

[2]

Synaptonemal complex protein 3, also known as SYCP3, is a human gene.^[1]

[edit] References

^ Entrez Gene: SYCP3 synaptonemal complex protein 3.

[edit] Further reading

Yuan L, Liu JG, Zhao J, et al. (2000). "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.". Mol. Cell 5 (1): 73–83. PMID 10678170.
Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.". Genome Res. 10 (6): 758–75. PMID 10854409.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMID 11591653.
Martinez-Garay I, Jablonka S, Sutajova M, et al. (2003). "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region.". Genomics 80 (3): 259–67. PMID 12213195.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee J, Iwai T, Yokota T, Yamashita M (2004). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis.". J. Cell. Sci. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
Miyamoto T, Hasuike S, Yogev L, et al. (2004). "Azoospermia in patients heterozygous for a mutation in SYCP3.". Lancet 362 (9397): 1714–9. PMID 14643120.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Boer P, Giele M, Lock MT, et al. (2004). "Kinetics of meiosis in azoospermic males: a joint histological and cytological approach.". Cytogenet. Genome Res. 105 (1): 36–46. doi:10.1159/000078007. PMID 15218256.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Stouffs K, Lissens W, Tournaye H, et al. (2006). "SYCP3 mutations are uncommon in patients with azoospermia.". Fertil. Steril. 84 (4): 1019–20. doi:10.1016/j.fertnstert.2005.04.033. PMID 16213863.
Aarabi M, Modarressi MH, Soltanghoraee H, et al. (2006). "Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia.". Fertil. Steril. 86 (2): 325–31. doi:10.1016/j.fertnstert.2005.12.070. PMID 16824523.
Sapkota G, Knockaert M, Alarcón C, et al. (2007). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.". J. Biol. Chem. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.
Martínez J, Bonache S, Carvajal A, et al. (2007). "Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest.". Fertil. Steril. 88 (4): 988–9. doi:10.1016/j.fertnstert.2006.11.163. PMID 17434513.