Talk:Swyer syndrome

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talk:Swyer syndrome/archive1 2004

[edit] if XY female mate with XY male?

A very intresting question came to my mind. If somehow by giving estrogen and other female hormones will it produce normal baby if it mates with an normal male?

There are no ovaries, hence no eggs, no pregnancy, no baby. alteripse 01:43, 30 March 2006 (UTC)

The only ways for a Swyer to have a baby are to either use someone else's embryo, or have a clone of themselves implanted through IV. (yes, I have pondered this kind of thing. I am a Swyer ;)) --60.229.153.253 10:47, 24 February 2007 (UTC) (Addition to the above: I don't know how advanced biology is, but some day it could be possible to clone a virile male version of myself by adding the SRY gene! That would be sweet)--138.130.124.108 05:47, 12 March 2007 (UTC)

[edit] I think we need an article on gonadal dysgenesis

Swyer syndrome is one type of gonadal dysgenesis. Rather than confusing mentions of a random assortment of some of the other forms of intersex or gonadal dysgenesis, we need an article on gonadal dysgenesis that explains the term and lists systematically the major forms. In the meantime, I parked some of Ekem's recent additions here because I think they confuse rather than inform the reader. The section either needs to be more complete or systematic (which would be longer than the rest of the article) or it needs to be part of an article on all the forms of gonadal dysgenesis. alteripse 15:50, 23 June 2006 (UTC)

Removed material:

Swyer syndrome results from a failure of one of the earliest stages of differentiation of a genetic male: translation of the SRY gene to initiate testicular development. In a minority of cases of apparent Swyer syndrome, some other very early defect of testicular development (testicular dysgenesis) occurs. Since estrogens are made from androgens, any severe defect of androgen production (e.g., congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency) will also produce estrogen deficiency and result in a failure of pubertal development in a girl with an XY karyotype. On the other hand, a defect of androgen action (e.g., androgen insensitivity syndrome) is readily distinguished because the breasts begin to develop normally without much delay, though pubic hair may be minimal.

There is a condition in 46,XX females where the ovaries fail to develop or become atretic prior to puberty: XX gonadal dysgenesis.

Anorchia refers to a condition in males whose testicular development arrests prior to birth but after the reproductive system has been masculinized.