Swainsonine

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Swainsonine
IUPAC name (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-Octahydroindolizine-

1,2,8-triol
Other names Tridolgosir
Identifiers
CAS number [72741-87-8]
PubChem 51683
SMILES C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
Properties
Molecular formula C8H15NO3
Molar mass 173.21 g mol-1
Melting point

143-144 °C
Solubility in water 10 mg/1 mL
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Swainsonine is a potent inhibitor of Golgi alpha-mannosidase II, immunomodulator and potential anticancer agent. Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. These glycans have a Man5GlcNAc2 core with processing on the 3-arm that resembles so-called complex-type glycans.

The pharmacological properties of this product have not been fully investigated.

[edit] Handling Instructions

  • Soluble in water (10 mg/1 ml) and ethanol
  • Use caution when handling.
  • This product must not be used in humans
  • Store between 0-4 ˚C for up to 1 year
  • Store or 20 ˚C for up to 3 months
  • Disposal: A

[edit] References