SUZ12

From Wikipedia, the free encyclopedia

Suppressor of zeste 12 homolog (Drosophila)

Identifiers

SUZ12; CHET9; JJAZ1; KIAA0160

External IDs

OMIM: 606245 MGI: 1261758 HomoloGene: 32256

Gene ontology
Molecular Function:	• nucleic acid binding • chromatin binding • zinc ion binding • histone methyltransferase activity • metal ion binding
Cellular Component:	• sex chromatin • intracellular • nucleus • ESC/E(Z) complex
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • positive regulation of cell proliferation • chromatin modification • histone methylation • histone ubiquitination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015355 (mRNA)
NP_056170 (protein)

NM_199196 (mRNA)
NP_954666 (protein)

Location

Chr 17: 27.29 - 27.35 Mb

Chr 11: 79.81 - 79.85 Mb

Pubmed search

[1]

[2]

Suppressor of zeste 12 homolog (Drosophila), also known as SUZ12, is a human gene.^[1]

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila).

[edit] Further reading

Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167-74, 199-210. PMID 8590280.
Koontz JI, Soreng AL, Nucci M, et al. (2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors.". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6348-53. doi:10.1073/pnas.101132598. PMID 11371647.
Birve A, Sengupta AK, Beuchle D, et al. (2001). "Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants.". Development 128 (17): 3371-9. PMID 11546753.
Weinmann AS, Bartley SM, Zhang T, et al. (2001). "Use of chromatin immunoprecipitation to clone novel E2F target promoters.". Mol. Cell. Biol. 21 (20): 6820-32. doi:10.1128/MCB.21.20.6820-6832.2001. PMID 11564866.
Cao R, Wang L, Wang H, et al. (2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing.". Science 298 (5595): 1039-43. doi:10.1126/science.1076997. PMID 12351676.
Kuzmichev A, Nishioka K, Erdjument-Bromage H, et al. (2002). "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.". Genes Dev. 16 (22): 2893-905. doi:10.1101/gad.1035902. PMID 12435631.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Petek E, Jenne DE, Smolle J, et al. (2003). "Mitotic recombination mediated by the JJAZF1 (KIAA0160) gene causing somatic mosaicism and a new type of constitutional NF1 microdeletion in two children of a mosaic female with only few manifestations.". J. Med. Genet. 40 (7): 520-5. PMID 12843325.
Wang H, An W, Cao R, et al. (2003). "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.". Mol. Cell 12 (2): 475-87. PMID 14536086.
Huang HY, Ladanyi M, Soslow RA (2004). "Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity.". Am. J. Surg. Pathol. 28 (2): 224-32. PMID 15043312.
Cao R, Zhang Y (2004). "SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.". Mol. Cell 15 (1): 57-67. doi:10.1016/j.molcel.2004.06.020. PMID 15225548.
Kehrer-Sawatzki H, Kluwe L, Sandig C, et al. (2004). "High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene.". Am. J. Hum. Genet. 75 (3): 410-23. doi:10.1086/423624. PMID 15257518.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Pasini D, Bracken AP, Jensen MR, et al. (2004). "Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.". EMBO J. 23 (20): 4061-71. doi:10.1038/sj.emboj.7600402. PMID 15385962.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Cha TL, Zhou BP, Xia W, et al. (2005). "Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.". Science 310 (5746): 306-10. doi:10.1126/science.1118947. PMID 16224021.
Lee TI, Jenner RG, Boyer LA, et al. (2006). "Control of developmental regulators by Polycomb in human embryonic stem cells.". Cell 125 (2): 301-13. doi:10.1016/j.cell.2006.02.043. PMID 16630818.
Furuno K, Masatsugu T, Sonoda M, et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro.". Biochem. Biophys. Res. Commun. 345 (3): 1051-8. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Nucci MR, Harburger D, Koontz J, et al. (2007). "Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms.". Am. J. Surg. Pathol. 31 (1): 65-70. doi:10.1097/01.pas.0000213327.86992.d1. PMID 17197920.