SUV39H2

From Wikipedia, the free encyclopedia

Suppressor of variegation 3-9 homolog 2 (Drosophila)

Identifiers

External IDs

OMIM: 606503 MGI: 1890396 HomoloGene: 32548

Gene ontology
Molecular Function:	• chromatin binding • protein binding • zinc ion binding • protein methyltransferase activity • transferase activity • histone lysine N-methyltransferase activity (H3-K9 specific)
Cellular Component:	• chromatin • nucleus • nuclear heterochromatin
Biological Process:	• chromatin assembly or disassembly • chromatin remodeling • male meiosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_024670 (mRNA)
NP_078946 (protein)

NM_022724 (mRNA)
NP_073561 (protein)

Location

Chr 10: 14.96 - 14.99 Mb

Chr 2: 3.37 - 3.39 Mb

Pubmed search

[1]

[2]

Suppressor of variegation 3-9 homolog 2 (Drosophila), also known as SUV39H2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Rea S, Eisenhaber F, O'Carroll D, et al. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases.". Nature 406 (6796): 593-9. doi:10.1038/35020506. PMID 10949293.
O'Carroll D, Scherthan H, Peters AH, et al. (2001). "Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression.". Mol. Cell. Biol. 20 (24): 9423-33. PMID 11094092.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Ait-Si-Ali S, Guasconi V, Fritsch L, et al. (2005). "A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.". EMBO J. 23 (3): 605-15. doi:10.1038/sj.emboj.7600074. PMID 14765126.
Frontelo P, Leader JE, Yoo N, et al. (2004). "Suv39h histone methyltransferases interact with Smads and cooperate in BMP-induced repression.". Oncogene 23 (30): 5242-51. doi:10.1038/sj.onc.1207660. PMID 15107829.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Yoon KA, Hwangbo B, Kim IJ, et al. (2006). "Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.". Carcinogenesis 27 (11): 2217-22. doi:10.1093/carcin/bgl084. PMID 16774942.