Surfactant protein D

From Wikipedia, the free encyclopedia

Surfactant, pulmonary-associated protein D

PDB rendering based on 1b08.

Available structures: 1b08, 1m7l, 1pw9, 1pwb, 2ggu, 2ggx, 2orj, 2ork, 2os9

Identifiers

Symbol(s)

SFTPD; COLEC7; PSP-D; SFTP4; SP-D

External IDs

OMIM: 178635 MGI: 109515 HomoloGene: 2272

Gene ontology
Molecular Function:	• calcium ion binding • sugar binding • bacterial binding
Cellular Component:	• extracellular region • cytoplasm • lysosome • endocytic vesicle
Biological Process:	• regulation of cytokine production • oxygen and reactive oxygen species metabolic process • phosphate transport • receptor-mediated endocytosis • respiratory gaseous exchange • antimicrobial humoral response • negative regulation of T cell proliferation • surfactant homeostasis • negative regulation of interleukin-2 biosynthetic process • innate immune response • macrophage chemotaxis • alveolus development • positive regulation of phagocytosis • regulation of liquid surface tension

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003019 (mRNA)
NP_003010 (protein)

NM_009160 (mRNA)
NP_033186 (protein)

Location

Chr 10: 81.69 - 81.7 Mb

Chr 14: 40.08 - 40.09 Mb

Pubmed search

[1]

[2]

Surfactant, pulmonary-associated protein D, also known as SFTPD, is is a collectin.^[1]

1 References
2 Further reading
3 See also
4 External links

[edit] References

^ Entrez Gene: SFTPD surfactant, pulmonary-associated protein D.

[edit] Further reading

Hansen S, Holmskov U (1999). "Structural aspects of collectins and receptors for collectins.". Immunobiology 199 (2): 165–89. PMID 9777404.
Lu J, Willis AC, Reid KB (1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D.". Biochem. J. 284 ( Pt 3): 795–802. PMID 1339284.
Ogasawara Y, Kuroki Y, Akino T (1992). "Pulmonary surfactant protein D specifically binds to phosphatidylinositol.". J. Biol. Chem. 267 (29): 21244–9. PMID 1400434.
Rust K, Grosso L, Zhang V, et al. (1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain.". Arch. Biochem. Biophys. 290 (1): 116–26. PMID 1898081.
Kuroki Y, Shiratori M, Ogasawara Y, et al. (1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids.". Biochim. Biophys. Acta 1086 (2): 185–90. PMID 1932100.
Crouch E, Persson A, Chang D, Heuser J (1994). "Molecular structure of pulmonary surfactant protein D (SP-D).". J. Biol. Chem. 269 (25): 17311–9. PMID 8006040.
Schaeffer E, Guillou F, Part D, Zakin MM (1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells.". J. Biol. Chem. 268 (31): 23399–408. PMID 8226864.
Kölble K, Lu J, Mole SE, et al. (1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster.". Genomics 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
Crouch E, Persson A, Chang D (1993). "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis.". Am. J. Pathol. 142 (1): 241–8. PMID 8424457.
Crouch E, Rust K, Veile R, et al. (1993). "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1.". J. Biol. Chem. 268 (4): 2976–83. PMID 8428971.
Rust K, Bingle L, Mariencheck W, et al. (1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids.". Am. J. Respir. Cell Mol. Biol. 14 (2): 121–30. PMID 8630261.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Holmskov U, Lawson P, Teisner B, et al. (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule.". J. Biol. Chem. 272 (21): 13743–9. PMID 9153228.
Botas C, Poulain F, Akiyama J, et al. (1998). "Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D.". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11869–74. PMID 9751757.
Håkansson K, Lim NK, Hoppe HJ, Reid KB (1999). "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D.". Structure 7 (3): 255–64. PMID 10368295.
Holmskov U, Mollenhauer J, Madsen J, et al. (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D.". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. PMID 10485905.
Lausen M, Lynch N, Schlosser A, et al. (1999). "Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D.". J. Biol. Chem. 274 (45): 32234–40. PMID 10542261.
Madsen J, Kliem A, Tornoe I, et al. (2000). "Localization of lung surfactant protein D on mucosal surfaces in human tissues.". J. Immunol. 164 (11): 5866–70. PMID 10820266.
Zhang L, Ikegami M, Crouch EC, et al. (2001). "Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.". J. Biol. Chem. 276 (22): 19214–9. doi:10.1074/jbc.M010191200. PMID 11278637.