SURF6

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Surfeit 6
Identifiers
Symbol(s) SURF6; FLJ30322
External IDs OMIM: 185642 MGI: 98447 HomoloGene: 44153
Orthologs
Human Mouse
Entrez 6838 20935
Ensembl ENSG00000148296 ENSMUSG00000036160
Uniprot O75683 Q3V1X4
Refseq NM_006753 (mRNA)
NP_006744 (protein)		 NM_009298 (mRNA)
NP_033324 (protein)
Location Chr 9: 135.19 - 135.19 Mb Chr 2: 26.71 - 26.72 Mb
Pubmed search [1] [2]

Surfeit 6, also known as SURF6, is a human gene.[1]

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.[1]

[edit] References

  1. ^ a b Entrez Gene: SURF6 surfeit 6.

[edit] Further reading

  • Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1.". Hum. Mol. Genet. 2 (3): 237–40. PMID 8499913. 
  • Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein.". DNA Cell Biol. 15 (4): 305–16. PMID 8639267. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. 
  • Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro.". Eur. J. Cell Biol. 75 (2): 174–83. PMID 9548374. 
  • Duhig T, Ruhrberg C, Mor O, Fried M (1999). "The human Surfeit locus.". Genomics 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673. 
  • Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus.". Gene 243 (1-2): 115–23. PMID 10675619. 
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. PMID 11790298. 
  • Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts.". Gene 284 (1-2): 169–78. PMID 11891058. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
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