Suppressor of cytokine signaling 1

From Wikipedia, the free encyclopedia

Identifiers

SOCS1; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3

External IDs

OMIM: 603597 MGI: 1354910 HomoloGene: 2776

Gene ontology
Molecular Function:	• protein kinase inhibitor activity • insulin-like growth factor receptor binding • protein binding • protein kinase binding
Cellular Component:	• cytoplasm
Biological Process:	• regulation of cell growth • regulation of protein amino acid phosphorylation • ubiquitin cycle • intracellular signaling cascade • JAK-STAT cascade • cytokine and chemokine mediated signaling pathway • negative regulation of tyrosine phosphorylation of Stat3 protein • fat cell differentiation • negative regulation of JAK-STAT cascade • negative regulation of insulin receptor signaling pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003745 (mRNA)
NP_003736 (protein)

NM_009896 (mRNA)
NP_034026 (protein)

Location

Chr 16: 11.26 - 11.26 Mb

Chr 16: 10.7 - 10.7 Mb

Pubmed search

[1]

[2]

Suppressor of cytokine signaling 1, also known as SOCS1, is a human gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.^[1]

[edit] See also

[edit] References

^ Entrez Gene: SOCS1 suppressor of cytokine signaling 1.

[edit] Further reading

Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling.". Stem Cells 19 (5): 378–87. PMID 11553846.
Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. PMID 11835308.
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Yoshimura A, Ohkubo T, Kiguchi T, et al. (1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.". EMBO J. 14 (12): 2816–26. PMID 7796808.
Starr R, Willson TA, Viney EM, et al. (1997). "A family of cytokine-inducible inhibitors of signalling.". Nature 387 (6636): 917–21. doi:10.1038/43206. PMID 9202125.
Endo TA, Masuhara M, Yokouchi M, et al. (1997). "A new protein containing an SH2 domain that inhibits JAK kinases.". Nature 387 (6636): 921–4. doi:10.1038/43213. PMID 9202126.
Minamoto S, Ikegame K, Ueno K, et al. (1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.". Biochem. Biophys. Res. Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
Ohya K, Kajigaya S, Yamashita Y, et al. (1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.". J. Biol. Chem. 272 (43): 27178–82. PMID 9341160.
Dey BR, Spence SL, Nissley P, Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.". J. Biol. Chem. 273 (37): 24095–101. PMID 9727029.
De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMID 10022833.
Zhang JG, Farley A, Nicholson SE, et al. (1999). "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2071–6. PMID 10051596.
Yasukawa H, Misawa H, Sakamoto H, et al. (1999). "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.". EMBO J. 18 (5): 1309–20. doi:10.1093/emboj/18.5.1309. PMID 10064597.
Marine JC, Topham DJ, McKay C, et al. (1999). "SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.". Cell 98 (5): 609–16. PMID 10490100.
Yandava CN, Pillari A, Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.". Genomics 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.
Okabe S, Tauchi T, Morita H, et al. (1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway.". Exp. Hematol. 27 (10): 1542–7. PMID 10517496.
Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.". J. Biol. Chem. 274 (50): 35553–61. PMID 10585430.
Sporri B, Kovanen PE, Sasaki A, et al. (2001). "JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.". Blood 97 (1): 221–6. PMID 11133764.
Kawazoe Y, Naka T, Fujimoto M, et al. (2001). "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.". J. Exp. Med. 193 (2): 263–9. PMID 11208867.
Bourette RP, De Sepulveda P, Arnaud S, et al. (2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal.". J. Biol. Chem. 276 (25): 22133–9. doi:10.1074/jbc.M101878200. PMID 11297560.
Mooney RA, Senn J, Cameron S, et al. (2001). "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.". J. Biol. Chem. 276 (28): 25889–93. doi:10.1074/jbc.M010579200. PMID 11342531.