SUPT4H1

From Wikipedia, the free encyclopedia

Suppressor of Ty 4 homolog 1 (S. cerevisiae)

Identifiers

SUPT4H1; SPT4H; SUPT4H

External IDs

OMIM: 603555 MGI: 107416 HomoloGene: 68303

Gene ontology
Molecular Function:	• transcription factor activity • negative transcription elongation factor activity • positive transcription elongation factor activity • zinc ion binding • metal ion binding • protein heterodimerization activity
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • chromatin remodeling • transcription • RNA elongation from RNA polymerase II promoter • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_003168 (mRNA)
NP_003159 (protein)

NM_009296 (mRNA)
NP_033322 (protein)

Location

n/a

Chr 11: 87.55 - 87.56 Mb

Pubmed search

[1]

[2]

Suppressor of Ty 4 homolog 1 (S. cerevisiae), also known as SUPT4H1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae).

[edit] Further reading

Hartzog GA, Basrai MA, Ricupero-Hovasse SL, et al. (1996). "Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae.". Mol. Cell. Biol. 16 (6): 2848–56. PMID 8649394.
Chiang PW, Wang SQ, Smithivas P, et al. (1996). "Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene.". Genomics 34 (3): 368–75. doi:10.1006/geno.1996.0299. PMID 8786137.
Wada T, Takagi T, Yamaguchi Y, et al. (1998). "DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.". Genes Dev. 12 (3): 343–56. PMID 9450929.
Wada T, Takagi T, Yamaguchi Y, et al. (1999). "Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.". EMBO J. 17 (24): 7395–403. doi:10.1093/emboj/17.24.7395. PMID 9857195.
Yamaguchi Y, Wada T, Watanabe D, et al. (1999). "Structure and function of the human transcription elongation factor DSIF.". J. Biol. Chem. 274 (12): 8085–92. PMID 10075709.
Yamaguchi Y, Takagi T, Wada T, et al. (1999). "NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.". Cell 97 (1): 41–51. PMID 10199401.
Kim JB, Yamaguchi Y, Wada T, et al. (1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins.". Mol. Cell. Biol. 19 (9): 5960–8. PMID 10454543.
Ivanov D, Kwak YT, Guo J, Gaynor RB (2000). "Domains in the SPT5 protein that modulate its transcriptional regulatory properties.". Mol. Cell. Biol. 20 (9): 2970–83. PMID 10757782.
Wada T, Orphanides G, Hasegawa J, et al. (2000). "FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.". Mol. Cell 5 (6): 1067–72. PMID 10912001.
Ping YH, Rana TM (2001). "DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.". J. Biol. Chem. 276 (16): 12951–8. doi:10.1074/jbc.M006130200. PMID 11112772.
Renner DB, Yamaguchi Y, Wada T, et al. (2001). "A highly purified RNA polymerase II elongation control system.". J. Biol. Chem. 276 (45): 42601–9. doi:10.1074/jbc.M104967200. PMID 11553615.
Mo X, Dynan WS (2002). "Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.". Mol. Cell. Biol. 22 (22): 8088–99. PMID 12391174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Narita T, Yamaguchi Y, Yano K, et al. (2003). "Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.". Mol. Cell. Biol. 23 (6): 1863–73. PMID 12612062.
Kim DK, Inukai N, Yamada T, et al. (2004). "Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex.". Genes Cells 8 (4): 371–8. PMID 12653964.
Kwak YT, Guo J, Prajapati S, et al. (2003). "Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.". Mol. Cell 11 (4): 1055–66. PMID 12718890.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Endoh M, Zhu W, Hasegawa J, et al. (2004). "Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.". Mol. Cell. Biol. 24 (8): 3324–36. PMID 15060154.
Mandal SS, Chu C, Wada T, et al. (2004). "Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II.". Proc. Natl. Acad. Sci. U.S.A. 101 (20): 7572–7. doi:10.1073/pnas.0401493101. PMID 15136722.
Jennings BH, Shah S, Yamaguchi Y, et al. (2005). "Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila.". Curr. Biol. 14 (18): 1680–4. doi:10.1016/j.cub.2004.08.066. PMID 15380072.