Sulfite reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, a sulfite reductase (NADPH) (EC 1.8.1.2) is an enzyme that catalyzes the chemical reaction

hydrogen sulfide + 3 NADP⁺ + 3 H₂O $\rightleftharpoons$ sulfite + 3 NADPH + 3 H⁺

The 3 substrates of this enzyme are hydrogen sulfide, NADP⁺, and H₂O, whereas its 3 products are sulfite, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen-sulfide:NADP+ oxidoreductase. Other names in common use include sulfite (reduced nicotinamide adenine dinucleotide phosphate), reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H2S-NADP oxidoreductase, and sulfite reductase (NADPH2). This enzyme participates in selenoamino acid metabolism and sulfur metabolism. It has 4 cofactors: FAD, Iron, Heme, and FMN.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes 1AOP, 1DDG, 1DDI, 1YKG, 2AOP, 2GEP, 3AOP, 3GEO, 4AOP, 4GEP, 5AOP, 5GEP, 6GEP, 7GEP, and 8GEP.

[edit] References

IUBMB entry for 1.8.1.2
BRENDA references for 1.8.1.2 (Recommended.)
PubMed references for 1.8.1.2
PubMed Central references for 1.8.1.2
Google Scholar references for 1.8.1.2
HILZ H, KITTLER M, KNAPE G (1959). "[The reduction of sulfate in yeast.]". Biochem. Z. 332: 151–66. PMID 14401842.
Siegel LM, Murphy MJ, Kamin H (1973). "Reduced nicotinamide adenine dinucleotide phosphate-sulfite reductase of enterobacteria. I. The Escherichia coli hemoflavoprotein: molecular parameters and prosthetic groups". J. Biol. Chem. 248: 251–64. PMID 4144254.
Yoshimoto A, Sato R (1968). "Studies on yeast sulfite reductase. I. Purification and characterization". Biochim. Biophys. Acta. 153: 555–75. PMID 4384979.