Sulfinoalanine decarboxylase

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In enzymology, a sulfinoalanine decarboxylase (EC 4.1.1.29) is an enzyme that catalyzes the chemical reaction

3-sulfino-L-alanine $\rightleftharpoons$ hypotaurine + CO₂

Hence, this enzyme has one substrate, 3-sulfino-L-alanine, and two products, hypotaurine and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming). Other names in common use include cysteine-sulfinate decarboxylase, L-cysteinesulfinic acid decarboxylase, cysteine-sulfinate decarboxylase, CADCase/CSADCase, CSAD, cysteic decarboxylase, cysteinesulfinic acid decarboxylase, cysteinesulfinate decarboxylase, sulfoalanine decarboxylase, and 3-sulfino-L-alanine carboxy-lyase. This enzyme participates in taurine and hypotaurine metabolism. It employs one cofactor, pyridoxal phosphate.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JIS.

[edit] References

IUBMB entry for 4.1.1.29
BRENDA references for 4.1.1.29 (Recommended.)
PubMed references for 4.1.1.29
PubMed Central references for 4.1.1.29
Google Scholar references for 4.1.1.29
Guion-Rain M-C, Portemer C, Chatagner F (1975). "Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties". Biochim. Biophys. Acta. 384: 265–76. PMID 236774.
JACOBSEN JG, THOMAS LL, SMITH LH Jr (1964). "PROPERTIES AND DISTRIBUTION OF MAMMALIAN L-CYSTEINE SULFINATE CARBOXY-LYASES". Biochim. Biophys. Acta. 85: 103–16. PMID 14159288.