Sulfate adenylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a sulfate adenylyltransferase (EC 2.7.7.4) is an enzyme that catalyzes the chemical reaction

ATP + sulfate $\rightleftharpoons$ diphosphate + adenylyl sulfate

Thus, the two substrates of this enzyme are ATP and sulfate, whereas its two products are diphosphate and adenylyl sulfate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:sulfate adenylyltransferase. Other names in common use include ATP-sulfurylase, adenosine-5'-triphosphate sulfurylase, adenosinetriphosphate sulfurylase, adenylylsulfate pyrophosphorylase, ATP sulfurylase, ATP-sulfurylase, and sulfurylase. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes 1G8F, 1G8G, 1G8H, 1I2D, 1J70, 1JEC, 1JED, 1JEE, 1JHD, 1M8P, 1R6X, 1TV6, 1V47, 1X6V, 1XJQ, 1XNJ, 1ZUN, and 2GKS.

[edit] References

IUBMB entry for 2.7.7.4
BRENDA references for 2.7.7.4 (Recommended.)
PubMed references for 2.7.7.4
PubMed Central references for 2.7.7.4
Google Scholar references for 2.7.7.4
Bandurski RS, Wilson LG, Squires CL (1956). "The mechanism of "active sulfate" formation". J. Am. Chem. Soc. 78: 6408–6409. doi:10.1021/ja01605a028.
Hilz H and Lipmann F (1955). "The enzymatic activation of sulfate". Proc. Natl. Acad. Sci. USA 41: 880–890. doi:10.1073/pnas.41.11.880.
Venkatachalam KV, Akita H, Strott CA (1998). "Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains". J. Biol. Chem. 273: 19311–20. doi:10.1074/jbc.273.30.19311. PMID 9668121.