SULT4A1

From Wikipedia, the free encyclopedia

Sulfotransferase family 4A, member 1

PDB rendering based on 1zd1.

Available structures: 1zd1

Identifiers

Symbol(s)

SULT4A1; BR-STL-1; BRSTL1; DJ388M5.3; MGC40032; NST; SULTX3; hBR-STL-1

External IDs

OMIM: 608359 MGI: 1888971 HomoloGene: 49378

Gene ontology
Molecular Function:	• sulfotransferase activity • transferase activity
Cellular Component:	• cytosol
Biological Process:	• lipid metabolic process • sulfur metabolic process • biological_process • steroid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014351 (mRNA)
NP_055166 (protein)

XM_001002084 (mRNA)
XP_001002084 (protein)

Location

Chr 22: 42.55 - 42.59 Mb

Chr 15: 83.9 - 83.93 Mb

Pubmed search

[1]

[2]

Sulfotransferase family 4A, member 1, also known as SULT4A1, is a human gene.^[1]

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.^[1]

[edit] References

^ ^a ^b Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1.

[edit] Further reading

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. PMID 9034160.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341–8. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141–70. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27–40. PMID 11535246.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Falany CN, Xie X, Wang J, et al. (2000). "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain.". Biochem. J. 346 Pt 3: 857–64. PMID 10698717.
Sakakibara Y, Suiko M, Pai TG, et al. (2002). "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization.". Gene 285 (1-2): 39–47. PMID 12039030.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22.". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMID 12529303.
Liyou NE, Buller KM, Tresillian MJ, et al. (2004). "Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study.". J. Histochem. Cytochem. 51 (12): 1655–64. PMID 14623933.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Brennan MD, Condra J (2006). "Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 (1): 69–72. doi:10.1002/ajmg.b.30222. PMID 16152568.
Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases.". PLoS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMID 17425406.