SULT1C4

From Wikipedia, the free encyclopedia

Sulfotransferase family, cytosolic, 1C, member 2

PDB rendering based on 2ad1.

Available structures: 2ad1, 2gwh

Identifiers

Symbol(s)

SULT1C2; MGC149521; MGC34422; SULT1C

External IDs

OMIM: 608357 HomoloGene: 41383

Gene ontology
Molecular Function:	• sulfotransferase activity • transferase activity
Cellular Component:	• cellular_component
Biological Process:	• biological_process

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_006588 (mRNA)
NP_006579 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 2: 108.36 - 108.37 Mb

n/a

Pubmed search

[1]

n/a

Sulfotransferase family, cytosolic, 1C, member 2, also known as SULT1C2, is a human gene.^[1]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds.^[1]

[edit] References

^ ^a ^b Entrez Gene: SULT1C2 sulfotransferase family, cytosolic, 1C, member 2.

[edit] Further reading

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. PMID 9034160.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341–8. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141–70. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27–40. PMID 11535246.
Sakakibara Y, Yanagisawa K, Katafuchi J, et al. (1999). "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene.". J. Biol. Chem. 273 (51): 33929–35. PMID 9852044.
Freimuth RR, Raftogianis RB, Wood TC, et al. (2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization.". Genomics 65 (2): 157–65. doi:10.1006/geno.2000.6150. PMID 10783263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases.". PLoS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMID 17425406.