SULT1C2

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Sulfotransferase family, cytosolic, 1C, member 1
PDB rendering based on 2etg.
Available structures: 2etg
Identifiers
Symbol(s) SULT1C1; ST1C1; ST1C2; SULT1C#1; humSULTC2
External IDs OMIM: 602385 HomoloGene: 88509
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6819 n/a
Ensembl ENSG00000198203 n/a
Uniprot O00338 n/a
Refseq NM_001056 (mRNA)
NP_001047 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 2: 108.27 - 108.29 Mb n/a
Pubmed search [1] n/a

Sulfotransferase family, cytosolic, 1C, member 1, also known as SULT1C1, is a human gene.[1]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: SULT1C1 sulfotransferase family, cytosolic, 1C, member 1.

[edit] Further reading

  • Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3-14. PMID 9034160. 
  • Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341-8. PMID 10720750. 
  • Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141-70. PMID 11154739. 
  • Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27-40. PMID 11535246. 
  • Kiehlbauch CC, Lam YF, Ringer DP (1995). "Homodimeric and heterodimeric aryl sulfotransferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene.". J. Biol. Chem. 270 (32): 18941-7. PMID 7642552. 
  • Her C, Kaur GP, Athwal RS, Weinshilboum RM (1997). "Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization.". Genomics 41 (3): 467-70. PMID 9169148. 
  • Yoshinari K, Nagata K, Shimada M, Yamazoe Y (1998). "Molecular characterization of ST1C1-related human sulfotransferase.". Carcinogenesis 19 (5): 951-3. PMID 9635888. 
  • Sakakibara Y, Yanagisawa K, Katafuchi J, et al. (1999). "Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene.". J. Biol. Chem. 273 (51): 33929-35. PMID 9852044. 
  • Hehonah N, Zhu X, Brix L, et al. (1999). "Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase.". Int. J. Biochem. Cell Biol. 31 (8): 869-82. PMID 10481272. 
  • Freimuth RR, Raftogianis RB, Wood TC, et al. (2000). "Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization.". Genomics 65 (2): 157-65. doi:10.1006/geno.2000.6150. PMID 10783263. 
  • Li X, Clemens DL, Anderson RJ (2000). "Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*.". Biochem. Pharmacol. 60 (11): 1713-6. PMID 11077054. 
  • Freimuth RR, Eckloff B, Wieben ED, Weinshilboum RM (2002). "Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies.". Pharmacogenetics 11 (9): 747-56. PMID 11740338. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Dombrovski L, Dong A, Bochkarev A, Plotnikov AN (2006). "Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).". Proteins 64 (4): 1091-4. doi:10.1002/prot.21048. PMID 16804942. 
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