SULT1A1

From Wikipedia, the free encyclopedia

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

PDB rendering based on 1cjm.

Available structures: 1cjm, 1ls6, 1z28, 1z29, 2a3r, 2d06

Identifiers

Symbol(s)

SULT1A1; P-PST; HAST1/HAST2; MGC131921; MGC5163; PST; ST1A3; STP; STP1; TSPST1

External IDs

OMIM: 171150 MGI: 102896 HomoloGene: 68152

Gene ontology
Molecular Function:	• aryl sulfotransferase activity • sulfotransferase activity • transferase activity
Biological Process:	• catecholamine metabolic process • lipid metabolic process • steroid metabolic process • amine metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001055 (mRNA)
NP_001046 (protein)

NM_133670 (mRNA)
NP_598431 (protein)

Location

Chr 16: 28.52 - 28.54 Mb

Chr 7: 126.46 - 126.47 Mb

Pubmed search

[1]

[2]

Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1, also known as SULT1A1, is a human gene.^[1]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1.

[edit] Further reading

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. PMID 9034160.
Windmill KF, Christiansen A, Teusner JT, et al. (1998). "Localisation of aryl sulfotransferase expression in human tissues using hybridisation histochemistry and immunohistochemistry.". Chem. Biol. Interact. 109 (1-3): 341–6. PMID 9566757.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113: 341–8. PMID 10720750.
Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141–70. PMID 11154739.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27–40. PMID 11535246.
Ozawa S, Nagata K, Shimada M, et al. (1995). "Primary structures and properties of two related forms of aryl sulfotransferases in human liver.". Pharmacogenetics 5 Spec No: S135–40. PMID 7581483.
Jones AL, Hagen M, Coughtrie MW, et al. (1995). "Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form.". Biochem. Biophys. Res. Commun. 208 (2): 855–62. doi:10.1006/bbrc.1995.1414. PMID 7695643.
Hwang SR, Kohn AB, Hook VY (1995). "Molecular cloning of an isoform of phenol sulfotransferase from human brain hippocampus.". Biochem. Biophys. Res. Commun. 207 (2): 701–7. PMID 7864863.
Yamazoe Y, Nagata K, Ozawa S, Kato R (1994). "Structural similarity and diversity of sulfotransferases.". Chem. Biol. Interact. 92 (1-3): 107–17. PMID 8033246.
Falany CN, Zhuang W, Falany JL (1994). "Characterization of expressed human phenol-sulfating phenol sulfotransferase: effect of mutating cys70 on activity and thermostability.". Chem. Biol. Interact. 92 (1-3): 57–66. PMID 8033270.
Veronese ME, Burgess W, Zhu X, McManus ME (1994). "Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies.". Biochem. J. 302 ( Pt 2): 497–502. PMID 8093002.
Dooley TP, Obermoeller RD, Leiter EH, et al. (1994). "Mapping of the phenol sulfotransferase gene (STP) to human chromosome 16p12.1-p11.2 and to mouse chromosome 7.". Genomics 18 (2): 440–3. doi:10.1006/geno.1993.1494. PMID 8288252.
Zhu X, Veronese ME, Bernard CC, et al. (1993). "Identification of two human brain aryl sulfotransferase cDNAs.". Biochem. Biophys. Res. Commun. 195 (1): 120–7. PMID 8363592.
Wilborn TW, Comer KA, Dooley TP, et al. (1993). "Sequence analysis and expression of the cDNA for the phenol-sulfating form of human liver phenol sulfotransferase.". Mol. Pharmacol. 43 (1): 70–7. PMID 8423770.
Zhu X, Veronese ME, Sansom LN, McManus ME (1993). "Molecular characterisation of a human aryl sulfotransferase cDNA.". Biochem. Biophys. Res. Commun. 192 (2): 671–6. PMID 8484775.
Her C, Raftogianis R, Weinshilboum RM (1996). "Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization.". Genomics 33 (3): 409–20. doi:10.1006/geno.1996.0216. PMID 8661000.
Dooley TP, Huang Z (1996). "Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16.". Biochem. Biophys. Res. Commun. 228 (1): 134–40. doi:10.1006/bbrc.1996.1628. PMID 8912648.
Bernier F, Soucy P, Luu-The V (1996). "Human phenol sulfotransferase gene contains two alternative promoters: Structure and expression of the gene.". DNA Cell Biol. 15 (5): 367–75. PMID 8924211.
Raftogianis RB, Her C, Weinshilboum RM (1997). "Human phenol sulfotransferase pharmacogenetics: STP1 gene cloning and structural characterization.". Pharmacogenetics 6 (6): 473–87. PMID 9014197.