SULF1

From Wikipedia, the free encyclopedia

Sulfatase 1

Identifiers

SULF1; FLJ30905; FLJ38022; FLJ41750; HSULF-1; KIAA1077; SULF-1

External IDs

OMIM: 610012 MGI: 2138563 HomoloGene: 49408

Gene ontology
Molecular Function:	• arylsulfatase activity • calcium ion binding • hydrolase activity
Cellular Component:	• extracellular space • endoplasmic reticulum • cell surface
Biological Process:	• apoptosis • metabolic process • heparan sulfate proteoglycan metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015170 (mRNA)
NP_055985 (protein)

NM_172294 (mRNA)
NP_758498 (protein)

Location

Chr 8: 70.54 - 70.74 Mb

Chr 1: 12.68 - 12.85 Mb

Pubmed search

[1]

[2]

Sulfatase 1, also known as SULF1, is a human gene.^[1]

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF1, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SULF1 sulfatase 1.

[edit] Further reading

Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197-205. PMID 10470851.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Morimoto-Tomita M, Uchimura K, Werb Z, et al. (2003). "Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.". J. Biol. Chem. 277 (51): 49175-85. doi:10.1074/jbc.M205131200. PMID 12368295.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lai J, Chien J, Staub J, et al. (2003). "Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.". J. Biol. Chem. 278 (25): 23107-17. doi:10.1074/jbc.M302203200. PMID 12686563.
Lai JP, Chien JR, Moser DR, et al. (2004). "hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling.". Gastroenterology 126 (1): 231-48. PMID 14699503.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Li J, Kleeff J, Abiatari I, et al. (2006). "Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer.". Mol. Cancer 4 (1): 14. doi:10.1186/1476-4598-4-14. PMID 15817123.
Dai Y, Yang Y, MacLeod V, et al. (2006). "HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo.". J. Biol. Chem. 280 (48): 40066-73. doi:10.1074/jbc.M508136200. PMID 16192265.
Narita K, Chien J, Mullany SA, et al. (2007). "Loss of HSulf-1 expression enhances autocrine signaling mediated by amphiregulin in breast cancer.". J. Biol. Chem. 282 (19): 14413-20. doi:10.1074/jbc.M611395200. PMID 17363371.
Backen AC, Cole CL, Lau SC, et al. (2007). "Heparan sulphate synthetic and editing enzymes in ovarian cancer.". Br. J. Cancer 96 (10): 1544-8. doi:10.1038/sj.bjc.6603747. PMID 17437011.