Talk:Suicide inhibition
From Wikipedia, the free encyclopedia
 |
This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Restriction enzyme. |
||
| Stub | This article has been rated as Stub-Class on the assessment scale. |
||
| Mid | This article is on a subject of Mid-importance within molecular and cellular biology. | ||
|
Article Grading: The article has been rated for quality and/or importance but has no comments yet. If appropriate, please review the article and then leave comments here to identify the strengths and weaknesses of the article and what work it will need. |
|||
 |
This article may be too technical for a general audience. Please help improve this article by providing more context and better explanations of technical details to make it more accessible, without removing technical details. |
What is a beta-gamma unsaturated carbon? How can a carbon atom be beta-gamma unsaturated? I also believe that there are other reactive intermediates formed, besides the three listed. For instance, Diisopropylfluorophosphate does not form any of the intermediates listed.
[edit] "normal"
"is a form of irreversible enzyme inhibition that occurs when an enzyme binds a substrate analogue and forms a complex with it during the "normal" catalysis reaction." This is very unclear? I am in my second year of chemistry and the explanation offered on the mechanism behind suiced inhibition is at best unclear. I understand what is meant but i think it needs a major rewrite: Suicide inhibition is the irrevesible inhibition of an enzyme by a substrate. It does this by undergoing some basic steps of the intented enzymatic reaction but instead of being releassed from the active site, the inhibitor has become a highly reactive complex which binds very strongly (and therefore irrevesibly) to the active site, thus achiving the permanent inhibition. Its called suicide inhibition because the inhibitor (and the enzyme) is destroyed. Is this any better? I am new to wikipedia and dont know how to go about editing... —Preceding unsigned comment added by Leonidaslundell (talk • contribs)
I'm not sure it has to bind to the active site. I'll check on that. David D. (Talk) 15:03, 15 September 2006 (UTC)
This page needs to list some references and further reading
Asd28 06:08, 3 July 2007 (UTC)
