SUGT1
From Wikipedia, the free encyclopedia
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
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PDB rendering based on 1rl1. | ||||||||||||||
Available structures: 1rl1 | ||||||||||||||
Identifiers | ||||||||||||||
Symbol(s) | SUGT1; SGT1 | |||||||||||||
External IDs | OMIM: 604098 MGI: 1915205 HomoloGene: 4877 | |||||||||||||
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Orthologs | ||||||||||||||
Human | Mouse | |||||||||||||
Entrez | 10910 | 67955 | ||||||||||||
Ensembl | ENSG00000165416 | ENSMUSG00000022024 | ||||||||||||
Uniprot | Q9Y2Z0 | Q9CRG3 | ||||||||||||
Refseq | NM_006704 (mRNA) NP_006695 (protein) |
NM_026474 (mRNA) NP_080750 (protein) |
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Location | Chr 13: 52.12 - 52.16 Mb | Chr 14: 78.32 - 78.36 Mb | ||||||||||||
Pubmed search | [1] | [2] |
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae), also known as SUGT1, is a human gene.[1]
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.[1]
[edit] References
[edit] Further reading
- Kitagawa K, Skowyra D, Elledge SJ, et al. (1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.". Mol. Cell 4 (1): 21–33. PMID 10445024.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: . PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi: . PMID 12665801.
- Nowotny M, Spiechowicz M, Jastrzebska B, et al. (2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.". J. Biol. Chem. 278 (29): 26923–8. doi: . PMID 12746458.
- Niikura Y, Kitagawa K (2004). "Identification of a novel splice variant: human SGT1B (SUGT1B).". DNA Seq. 14 (6): 436–41. PMID 15018354.
- Zou X, Ji C, Wang L, et al. (2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1.". DNA Seq. 15 (2): 140–3. PMID 15346769.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi: . PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi: . PMID 15592455.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi: . PMID 16964243.
- da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (2007). "SGT1 is essential for Nod1 activation.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6764–9. doi: . PMID 17420470.
- Spiechowicz M, Zylicz A, Bieganowski P, et al. (2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6.". Biochem. Biophys. Res. Commun. 357 (4): 1148–53. doi: . PMID 17466273.