SUGT1

From Wikipedia, the free encyclopedia


SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
PDB rendering based on 1rl1.
Available structures: 1rl1
Identifiers
Symbol(s) SUGT1; SGT1
External IDs OMIM: 604098 MGI1915205 HomoloGene4877
Orthologs
Human Mouse
Entrez 10910 67955
Ensembl ENSG00000165416 ENSMUSG00000022024
Uniprot Q9Y2Z0 Q9CRG3
Refseq NM_006704 (mRNA)
NP_006695 (protein)
NM_026474 (mRNA)
NP_080750 (protein)
Location Chr 13: 52.12 - 52.16 Mb Chr 14: 78.32 - 78.36 Mb
Pubmed search [1] [2]

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae), also known as SUGT1, is a human gene.[1]

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.[1]

[edit] References

[edit] Further reading

  • Kitagawa K, Skowyra D, Elledge SJ, et al. (1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex.". Mol. Cell 4 (1): 21–33. PMID 10445024. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Nowotny M, Spiechowicz M, Jastrzebska B, et al. (2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.". J. Biol. Chem. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458. 
  • Niikura Y, Kitagawa K (2004). "Identification of a novel splice variant: human SGT1B (SUGT1B).". DNA Seq. 14 (6): 436–41. PMID 15018354. 
  • Zou X, Ji C, Wang L, et al. (2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1.". DNA Seq. 15 (2): 140–3. PMID 15346769. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. 
  • da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (2007). "SGT1 is essential for Nod1 activation.". Proc. Natl. Acad. Sci. U.S.A. 104 (16): 6764–9. doi:10.1073/pnas.0610926104. PMID 17420470. 
  • Spiechowicz M, Zylicz A, Bieganowski P, et al. (2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6.". Biochem. Biophys. Res. Commun. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.